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Rigshospitalet - a part of Copenhagen University Hospital
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Multicriteria decision analysis process to develop new classification criteria for systemic lupus erythematosus

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  • Sara K Tedeschi
  • Sindhu R Johnson
  • Dimitrios T Boumpas
  • David Daikh
  • Thomas Dörner
  • Betty Diamond
  • Søren Jacobsen
  • David Jayne
  • Diane L Kamen
  • W Joseph McCune
  • Marta Mosca
  • Rosalind Ramsey-Goldman
  • Guillermo Ruiz-Irastorza
  • Matthias Schneider
  • Murray Urowitz
  • David Wofsy
  • Josef S Smolen
  • Raymond P Naden
  • Martin Aringer
  • Karen H Costenbader
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European League Against Rheumatism and are jointly supporting multiphase development of systemic lupus erythematosus (SLE) classification criteria based on weighted criteria and a continuous probability scale. Prior steps included item generation, item reduction and hierarchical organisation of candidate criteria using an evidence-based approach. Our objectives were to determine relative weights using multicriteria decision analysis (MCDA) and to set a provisional threshold score for SLE classification. An SLE Expert Panel (8 European, 9 North American) submitted 164 real, unique cases with a wide range of SLE probability in a standardised format. Using the candidate criteria, experts scored and rank-ordered 20 representative cases. At an in-person meeting, experts reviewed inter-rater reliability of scoring, further refined criteria definitions and participated in an MCDA exercise. Based on expert consensus decisions on pairwise comparisons of criteria, 1000minds software calculated criteria weights and rank-ordered the remaining 144 cases based on their additive scores. The score of the lowest-ranked case for which complete expert consensus was achieved defined the provisional threshold classification score. Inter-rater reliability of scoring cases with the candidate criteria was good. MCDA involved 74 pairwise decisions and was repeated for the arthritis and mucocutaneous domains when the initial ranking of some cases did not match expert opinion. After criteria weights and additive scores were recalculated once, experts reached consensus for SLE classification for all cases scoring>83. Using an iterative process, the candidate criteria definitions were refined, preliminary weights were calculated and a provisional threshold score for SLE classification was determined.

Original languageEnglish
JournalAnnals of the Rheumatic Diseases
Volume78
Issue number5
Pages (from-to)634-640
Number of pages7
ISSN0003-4967
DOIs
Publication statusPublished - May 2019

    Research areas

  • Consensus, Decision Support Techniques, Humans, Lupus Erythematosus, Systemic/classification, Reproducibility of Results, Rheumatology/methods

ID: 58902167