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Mortality of mothers from cardiovascular and non-cardiovascular causes following pregnancy complications in first delivery

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  1. Risk factors for weight faltering in infancy according to age at onset

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  1. Blødning i tredje trimester og placentakomplikationer

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  3. Continuous focus on preventive strategies and follow-up is important for a change

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  4. Epidemiology of placenta previa accreta: a systematic review and meta-analysis

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The combined effects of preterm delivery, small-for-gestational-age offspring, hypertensive disorders of pregnancy, placental abruption and stillbirth on early maternal death from cardiovascular causes have not previously been described in a large cohort. We investigated the effects of pregnancy complications on early maternal death in a registry-based retrospective cohort study of 782 287 women with a first singleton delivery in Denmark 1978-2007, followed for a median of 14.8 years (range 0.25-30.2) accruing 11.6 million person-years. We employed Cox proportional hazard models of early death from cardiovascular and non-cardiovascular causes following preterm delivery, small-for-gestational-age offspring and hypertensive disorders of pregnancy. We found that preterm delivery and small-for-gestational-age were both associated with subsequent death of mothers from cardiovascular and non-cardiovascular causes. Severe pre-eclampsia was associated with death from cardiovascular causes only. There was a less than additive effect on cardiovascular mortality hazard ratios with increasing number of pregnancy complications: preterm delivery 1.90 [95% confidence intervals 1.49, 2.43]; preterm delivery and small-for-gestational-age offspring 3.30 [2.25, 4.84]; preterm delivery, small-for-gestational-age offspring and pre-eclampsia 3.85 [2.07, 7.19]. Thus, we conclude that, separately and combined, preterm delivery and small-for-gestational-age are strong markers of early maternal death from both cardiovascular and non-cardiovascular causes, while hypertensive disorders of pregnancy are markers of early death of mothers from cardiovascular causes.
Original languageEnglish
JournalPaediatric and Perinatal Epidemiology (Print)
Volume24
Issue number4
Pages (from-to)323-30
Number of pages8
ISSN0269-5022
DOIs
Publication statusPublished - 1 Jul 2010

ID: 32184015