Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Mortality and ventricular arrhythmia after acute myocarditis: a nationwide registry-based follow-up study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Nationwide prevalence and characteristics of transthyretin amyloid cardiomyopathy in Sweden

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Effect of moderate potassium-elevating treatment in long QT syndrome: the TriQarr Potassium Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ticagrelor and the risk of Staphylococcus aureus bacteraemia and other infections

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Impact of Sacubitril/Valsartan Versus Ramipril on Total Heart Failure Events in the PARADISE-MI Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Kristian Hay Kragholm
  • Filip Lyng Lindgren
  • Tomas Zaremba
  • Phillip Freeman
  • Niels Holmark Andersen
  • Sam Riahi
  • Manan Pareek
  • Lars Køber
  • Christian Torp-Pedersen
  • Peter Søgaard
  • Andreas Hagendorff
  • Bhupendar Tayal
View graph of relations

Objective Incidence and severity of acute myocarditis vary significantly in previous reports and there is a lack of epidemiological studies on the short-term risks of mortality, heart failure and ventricular arrhythmias in patients with acute myocarditis. Therefore, study aims were to examine 90-day risks of mortality, heart failure (HF) and ventricular arrhythmias in patients with acute myocarditis in comparison to age-matched and sex-matched background population controls. Methods In this nationwide register-based follow-up study of patients hospitalised with myocarditis between 2002 and 2018 in Denmark, 90-day risks of all-cause mortality, HF, ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation (VF)), cardiac arrest and implantable cardioverter-defibrillator (ICD) implantation were compared with age-matched and sex-matched controls from the background population (1:5 matching). Absolute risks standardised to the age, sex and comorbidity distribution of the entire study population were derived from multivariable Cox regression. Results A total of 2523 patients hospitalised with myocarditis were included. Median age was 48 years (Q1-Q3: 30-69) and 67.7% were men. Comorbidity burden was more pronounced among patients with myocarditis relative to controls. Standardised 90-day all-cause mortality risk was 4.9% for patients with acute myocarditis versus 0.3% for controls (p<0.001). Ninety-day standardised risks for other endpoints were 7.5% versus 0.1% for HF, 1.9% versus <0.1% for VF/VF/arrest risk and 1.6% versus <0.1% for ICD implantation (all p<0.001). Conclusions In this large nationwide register-based follow-up study, patients hospitalised with myocarditis had significantly higher 90-day risks of all-cause mortality, HF, ventricular arrhythmias, cardiac arrest and ICD implantation compared with background population controls.

Original languageEnglish
Article numbere001806
JournalOpen Heart
Volume8
Issue number2
Pages (from-to)e001806
Number of pages8
ISSN2053-3624
DOIs
Publication statusPublished - 21 Oct 2021

Bibliographical note

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

    Research areas

  • Defibrillators, Implantable, Myocarditis, Tachycardia, Ventricular, Ventricular fibrillation

ID: 68763681