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Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults

Research output: Contribution to journalJournal articleResearchpeer-review


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  • Mia Demant
  • Malte P Suppli
  • Signe Foghsgaard
  • Lise Gether
  • Magnus F G Grøndahl
  • Niels B Dalsgaard
  • Sigrid S Bergmann
  • Amalie R Lanng
  • Lærke S Gasbjerg
  • Martin Thomasen
  • Jonatan I Bagger
  • Charlotte Strandberg
  • Merete J Kønig
  • Henning Grønbæk
  • Ulrik Becker
  • Nicolai J Wewer Albrechtsen
  • Jens J Holst
  • Joachim Knop
  • Matthew P Gillum
  • Tina Vilsbøll
  • Filip K Knop
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Aims/hypothesis: Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (1 week of binge drinking and junk food consumption) in young, healthy males.

Methods: Fourteen festival participants (FP) were studied before, during and after 1 week's participation in Roskilde Festival. Fourteen matched controls (CTRL) who did not participate in Roskilde Festival or change their lifestyle in other ways were investigated along a similar timeline.

Results: The FP group consumed more alcohol compared to their standard living conditions (2.0 ± 3.9 vs 16.3 ± 8.3 units/day, P < 0.001). CTRLs did not change their alcohol consumption. AUC for glucose during OGTT did not change in either group. C-peptide responses increased in the FP group (206 ± 24 vs 236 ± 17 min × nmol/L, P = 0.052) and the Matsuda index of insulin sensitivity decreased (6.2 ± 2.4 vs 4.7 ± 1.4, P = 0.054). AUC for glucagon during oral glucose tolerance test (OGTT) increased in the FP group (1037 ± 90 vs 1562 ± 195 min × pmol/L, P = 0.003) together with fasting fibroblast growth factor 21 (FGF21) (62 ± 30 vs 132 ± 72 pmol/L, P < 0.001), growth differentiation factor 15 (GDF5) (276 ± 78 vs 330 ± 83 pg/mL, P = 0.009) and aspartate aminotransferase (AST) levels (37.6 ± 6.8 vs 42.4 ± 11 U/L, P = 0.043). Four participants (29%) developed ultrasound-detectable steatosis and a mean strain elastography-assessed liver stiffness increased (P = 0.026) in the FP group.

Conclusions/Interpretation: Participation in Roskilde Festival did not affect oral glucose tolerance but was associated with a reduction in insulin sensitivity, increases in glucagon, FGF21, GDF15 and AST and lead to increased liver stiffness and, in 29% of the participants, ultrasound-detectable hepatic steatosis.

Original languageEnglish
JournalEuropean Journal of Endocrinology
Issue number1
Pages (from-to)23-32
Number of pages10
Publication statusPublished - 21 May 2021

    Research areas

  • Adult, Aspartate Aminotransferases/metabolism, Binge Drinking/metabolism, Blood Glucose/metabolism, C-Peptide/metabolism, C-Reactive Protein/metabolism, Denmark, Diet, Elasticity Imaging Techniques, Fast Foods, Fatty Liver/diagnostic imaging, Fibroblast Growth Factors/metabolism, Glucagon/metabolism, Glucose Tolerance Test, Growth Differentiation Factor 15/metabolism, Holidays, Humans, Insulin Resistance, Liver/diagnostic imaging, Male, Young Adult

ID: 65895981