Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Measurement of peripheral arterial tonometry in patients with diabetic foot ulcers during courses of hyperbaric oxygen treatment

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Only minor stem cell mobilization in head and neck irradiated patients treated with hyperbaric oxygen

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Eubs president's message

    Research output: Contribution to journalComment/debateResearchpeer-review

  3. Danish diving-related fatalities 1999-2012

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Decompression illness treated in Denmark 1999-2013

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Monitoring cardiac output during hyperbaric oxygen treatment of haemodynamically unstable patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Evaluation of Serum Insulin-like Factor 3 Quantification by LC-MS/MS as a Biomarker of Leydig Cell Function

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Treatment of diabetic foot ulcers is complex and often protracted. Hyperbaric oxygen treatment (HBOT) improves wound healing in diabetic ulcers and serves as an important adjunct to regular diabetic wound care. Endothelial dysfunction plays a central role in diabetes-related vascular complications and may be evaluated by a non-invasive technique called peripheral arterial tonometry which measures a reactive hyperaemia index (RHI). We hypothesized that endothelial function measured by peripheral arterial tonometry is impaired in diabetic foot ulcer patients and that HBOT might improve endothelial function.

METHODS: Endothelial function was prospectively assessed by peripheral arterial tonometry in 22 subjects with diabetic foot ulcers and 17 subjects without diabetes during courses of HBOT. Endothelial function was evaluated before first (baseline) and 30th treatments, and at 90-day follow-up. Serum insulin growth factor-I (IGF-I) concentrations were determined by immunoassay. Results were compared to 23 healthy subjects.

RESULTS: No baseline differences were found in endothelial function between subjects with diabetes, HBOT patients without-diabetes and healthy control subjects (RHI; 1.26, 1.61 and 1.81, respectively). No significant changes in RHI were found in patients with (P = 0.17) or without (P = 0.30) diabetes during courses of HBOT. At 90-day follow-up IGF-I was significantly reduced in the subjects with diabetes (P = 0.001) and unchanged in the group without diabetes (P = 0.99).

CONCLUSIONS: We found no significant differences in RHI between subjects with diabetic foot ulcers and patients without diabetes, nor improvement in endothelial function assessed by peripheral arterial tonometry during courses of HBOT.

Original languageEnglish
JournalDiving and Hyperbaric Medicine
Volume50
Issue number1
Pages (from-to)17-23
Number of pages7
ISSN1833-3516
DOIs
Publication statusPublished - 31 Mar 2020

ID: 59609866