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Rigshospitalet - a part of Copenhagen University Hospital
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Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; A prospective cohort study

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Background: Prenatal phthalate exposure has been suggested to alter immune responses and increase the risk of asthma, eczema and rhinitis. However, few studies have examined the effects in prospective cohorts and only one examined rhinitis. We therefore studied associations between maternal urinary concentrations of phthalate metabolites and asthma, eczema and rhinitis in offspring aged 5 years. Methods: From 552 pregnant women in the Odense Child Cohort, we quantified urinary concentrations of 12 phthalate metabolites in third trimester. We assessed asthma, rhinitis and eczema in their offspring at age 5 years with a questionnaire based on the International Study of Asthma and Allergies in Childhood (ISAAC), and conducted logistic regression adjusting for relevant confounders. Results: 7.4% of the children had asthma, 11.7% eczema and 9.2% rhinitis. Phthalate exposure was low compared to previous cohorts. No significant associations between prenatal phthalate exposure and asthma were found. Odds ratios (ORs) of child rhinitis with a doubling in ςDiNPm and di-2-ethylhexyl phthalate metabolite (ςDEHPm) concentrations were, respectively, 1.15 (95% confidence interval (CI) 0.97,1.36) and 1.21 (CI 0.93,1.58). The OR of eczema when doubling ςDiNPm was 1.24 (CI 1.00,1.55), whereas the OR of using medicine against eczema when doubling a di-ethyl phthalate (DEP) metabolite was 0.81 (CI 0.68,0.96). Conclusion: The lack of association between maternal phthalate exposure and asthma in the offspring may be due to low exposure and difficulties in determining asthma in 5-year-olds. The higher odds of rhinitis may raise public concern but further research in larger cohorts of older children is warranted.

Original languageEnglish
Article number32
JournalEnvironmental Health: A Global Access Science Source
Volume19
Issue number1
Pages (from-to)32
ISSN1476-069X
DOIs
Publication statusPublished - 13 Mar 2020

    Research areas

  • Allergic rhinitis, Asthma, Endocrine disrupting chemicals, Phthalate exposure, sEczema, Environmental Pollutants/adverse effects, Prevalence, Prospective Studies, Humans, Asthma/chemically induced, Rhinitis/chemically induced, Male, Phthalic Acids/adverse effects, Pregnancy Trimester, Third, Pregnancy, Denmark/epidemiology, Prenatal Exposure Delayed Effects/chemically induced, Eczema/chemically induced, Female, Plasticizers/adverse effects, Maternal Exposure/adverse effects, Child

ID: 59732605