Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Male Sexual Function after Allogeneic Hematopoietic Stem Cell Transplantation in Childhood: A Multicenter Study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Evaluation of Circulating miRNA Biomarkers of Testicular Germ Cell Tumors during Therapy and Follow-up-A Copenhagen Experience

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal Melanoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Predicting visual acuity deterioration and radiation-induced toxicities after brachytherapy for choroidal melanomas

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Longitudinal Increases in Serum Insulin-like Factor 3 and Testosterone Determined by LC-MS/MS in Pubertal Danish Boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Marked increase in incident gynecomastia: a 20-year national registry study, 1998 to 2017

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Marked Increase in Incident Gynecomastia: A 20-Year National Registry Study, 1998 to 2017

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

There are many known endocrine complications after allogeneic hematopoietic stem cell transplantation (HSCT) in childhood including increased risk of biochemical hypogonadism. However, little is known about sexuality in adulthood following childhood HSCT. In this multicenter study, sexual functions and possible risk factors were assessed comprehensively in two national cohorts (Finland and Denmark) of male adult survivors of childhood HSCT. Compared to a healthy control group (n = 56), HSCT survivors (n = 97) reported less sexual fantasies, poorer orgasms, lower sexual activity with a partner and reduced satisfaction with their sex life, even in the presence of normal erectile functions and a similar frequency of autoerotic acts. Of the HSCT survivors, 35% were cohabitating/married and 66% were sexually active. Risk factors for poorer self-reported sexual functions were partner status (not cohabitating with a partner), depressive symptoms, CNS and testicular irradiation. Sexual dysfunction increased by age in the HSCT group with a pace comparable to that of the control group. However, because of the lower baseline level of sexual functions in the HSCT group, they will reach the level of clinically significant dysfunction at a younger age. Hence, male survivors of childhood HSCT should be interviewed in detail about their sexual health beyond erectile functions.

Original languageEnglish
JournalCancers
Volume12
Issue number7
ISSN2072-6694
DOIs
Publication statusPublished - 4 Jul 2020

ID: 60546911