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Rigshospitalet - a part of Copenhagen University Hospital
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Magnesium sulphate treatment decreases the risk of cerebral palsy after preterm birth

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Children born preterm have an increased risk of severe morbidity, e.g. cerebral palsy (CP), compared to children born at term. CP cannot be treated, which is why a prophylactic approach is essential, as argued in this review. Six randomised controlled trials (RCTs) have provided data on MgSO4 treatment as CP neuroprotection in preterm birth, including a new RCT from Denmark. Recently, an updated meta-analysis with trial sequential analysis detected a significant neuroprotective effect of MgSO4 treatment in preterm birth. There is now sufficient evidence, that MgSO4 treatment should be used as neuroprotection in preterm birth.

Original languageEnglish
JournalUgeskrift for Laeger
Volume182
Issue number47
ISSN0041-5782
Publication statusPublished - 16 Nov 2020

ID: 61730534