Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Macular spatial distribution of preserved autofluorescence in patients with choroideremia

Research output: Contribution to journalJournal articleResearchpeer-review

  1. International multicentre retrospective cohort study of ocular adnexal marginal zone B-cell lymphoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Early postnatal hyperglycaemia is a risk factor for treatment-demanding retinopathy of prematurity

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Multimodal imaging of small hard retinal drusen in young healthy adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Retinal hemangioblastoma: prevalence, incidence and frequency of underlying von Hippel-Lindau disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Small Hard Macular Drusen and Associations in 11- to 12-Year-Old Children in the Copenhagen Child Cohort 2000 Eye Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Visual acuity and amblyopia prevalence in 11- to 12-year-old Danish children from the Copenhagen Child Cohort 2000

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Macular perfusion velocities in the ocular ischaemic syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Presbyopibehandling

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Amir H Hariri
  • Michael S Ip
  • Aniz Girach
  • Byron L Lam
  • M Dominik Fischer
  • Eeva-Marja Sankila
  • Mark Edward Pennesi
  • Frank G Holz
  • Robert E Maclaren
  • David G Birch
  • Carel B Hoyng
  • Ian M MacDonald
  • Graeme C Black
  • Stephen H Tsang
  • Neil M Bressler
  • Kimberly E Stepien
  • Michael Larsen
  • Michael B Gorin
  • Isabelle Meunier
  • Andrew R Webster
  • SriniVas Sadda
View graph of relations

BACKGROUND/AIMS: To better understand the pattern of degeneration progression in cases with choroideremia.

METHODS: A cohort of genotypically confirmed choroideremia cases who underwent optical coherence tomography (OCT) and fundus autofluorescence (FAF) imaging was studied. Using HEYEX review software, the foveal centre was marked on FAF images under guidance of corresponding OCT images, followed by application of an ETDRS grid. The boundaries of preserved autofluorescence (AF) were manually segmented in each individual ETDRS subfield. The regional distribution of preserved AF was assessed by comparing its area among the various subfields.

RESULTS: A total of 168 eyes from 84 choroideremia cases were enrolled. There was a statistically significant difference in the amount of preserved AF area between inner subfields as determined by one-way analysis of variance (F (3,668)=9.997, p<0.001) and also between outer subfields (F (3,668)=8.348, p<0.001). A Tukey posthoc test revealed that the preserved AF area in the nasal subfields in both the inner and outer subfields was significantly smaller compared with analogue subfields.

CONCLUSION: The asymmetric spatial distribution of preserved AF in choroideremia (corresponding to the stellate shaped nature of these regions) suggests that the progression of degeneration has directional preference.

Original languageEnglish
JournalThe British journal of ophthalmology
Volume103
Issue number7
Pages (from-to)933-937
ISSN0007-1161
DOIs
Publication statusPublished - Jul 2019

Bibliographical note

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

    Research areas

  • choroideremia, ellipsoid zone, fundus autofluorescence, optical coherence tomography, preserved autofluorescence, retinal pigment epithelium

ID: 56583982