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Rigshospitalet - a part of Copenhagen University Hospital
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L-serine: a neglected amino acid with a potential therapeutic role in diabetes

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L-serine is classified as a non-essential amino acid; however, L-serine is indispensable having a central role in a broad range of cellular processes. Growing evidence suggests a role for L-serine in the development of diabetes mellitus and its related complications, with L-serine being positively correlated to insulin secretion and sensitivity. L-serine metabolism is altered in type 1, type 2, and gestational diabetes, and L-serine supplementations improve glucose homeostasis and mitochondrial function, and reduce neuronal death. Additionally, L-serine lowers the incidence of autoimmune diabetes in NOD mice. Dietary supplementations of L-serine are generally regarded as safe (GRAS) by the FDA. Therefore, we believe that L-serine should be considered as an emerging therapeutic option in diabetes, although work remains in order to fully understand the role of L-serine in diabetes.

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume127
Issue number10
Pages (from-to)655-659
Number of pages5
ISSN0903-4641
DOIs
Publication statusPublished - Oct 2019

    Research areas

  • Animals, Diabetes Mellitus, Type 1/drug therapy, Diabetes Mellitus, Type 2/drug therapy, Diabetes, Gestational/drug therapy, Dietary Supplements, Disease Models, Animal, Female, Hypoglycemic Agents/administration & dosage, Pregnancy, Serine/administration & dosage, Treatment Outcome

ID: 59203709