Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Long-term Safety of Growth Hormone in Adults With Growth Hormone Deficiency: Overview of 15 809 GH-Treated Patients

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. A Biphasic Pattern of Reproductive Hormones in Healthy Female Infants -The COPENHAGEN Minipuberty Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Home blood pressure for the prediction of preeclampsia in women with pre-existing diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long-term follow-up on morbidity among women with a history of gestational diabetes mellitus: a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  4. The impact of suppressing estradiol during ovarian stimulation on the unsupported luteal phase: A Randomized Controlled Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Impact of Polymorphism in the β2-Receptor Gene on Metabolic Responses to Repeated Hypoglycemia in Healthy Humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Pituitary function and the response to GH therapy in patients with Langerhans Cell Histiocytosis: Analysis of the KIMS Database

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Approach to the patient with glucocorticoid-induced adrenal insufficiency

    Research output: Contribution to journalReviewResearchpeer-review

  3. Severe weight loss in a hypothyroid patient as an acute presentation of autoimmune polyglandular syndrome type II

    Research output: Contribution to journalReviewResearchpeer-review

  • Gudmundur Johannsson
  • Philippe Touraine
  • Ulla Feldt-Rasmussen
  • Antonio Pico
  • Greisa Vila
  • Anders F Mattsson
  • Martin Carlsson
  • Márta Korbonits
  • André P van Beek
  • Michael P Wajnrajch
  • Roy Gomez
  • Kevin C J Yuen
View graph of relations

CONTEXT: Data on long-term safety of growth hormone (GH) replacement in adults with GH deficiency (GHD) are needed.

OBJECTIVE: We aimed to evaluate the safety of GH in the full KIMS (Pfizer International Metabolic Database) cohort.

METHODS: The worldwide, observational KIMS study included adults and adolescents with confirmed GHD. Patients were treated with GH (Genotropin [somatropin]; Pfizer, NY) and followed through routine clinical practice. Adverse events (AEs) and clinical characteristics (eg, lipid profile, glucose) were collected.

RESULTS: A cohort of 15 809 GH-treated patients were analyzed (mean follow-up of 5.3 years). AEs were reported in 51.2% of patients (treatment-related in 18.8%). Crude AE rate was higher in patients who were older, had GHD due to pituitary/hypothalamic tumors, or adult-onset GHD. AE rate analysis adjusted for age, gender, etiology, and follow-up time showed no correlation with GH dose. A total of 606 deaths (3.8%) were reported (146 by neoplasms, 71 by cardiac/vascular disorders, 48 by cerebrovascular disorders). Overall, de novo cancer incidence was comparable to that in the general population (standard incidence ratio 0.92; 95% CI, 0.83-1.01). De novo cancer risk was significantly lower in patients with idiopathic/congenital GHD (0.64; 0.43-0.91), but similar in those with pituitary/hypothalamic tumors or other etiologies versus the general population. Neither adult-onset nor childhood-onset GHD was associated with increased de novo cancer risks. Neutral effects were observed in lipids/fasting blood glucose levels.

CONCLUSION: These final KIMS cohort data support the safety of long-term GH replacement in adults with GHD as prescribed in routine clinical practice.

Original languageEnglish
JournalThe Journal of clinical endocrinology and metabolism
Volume107
Issue number7
Pages (from-to)1906-1919
Number of pages14
ISSN0021-972X
DOIs
Publication statusPublished - 16 Jun 2022

Bibliographical note

© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.

    Research areas

  • Adolescent, Adult, Child, Dwarfism, Pituitary/complications, Growth Hormone/therapeutic use, Hormone Replacement Therapy/adverse effects, Human Growth Hormone/adverse effects, Humans, Hypopituitarism/drug therapy, Pituitary Diseases/etiology, Pituitary Neoplasms/drug therapy

ID: 79502519