Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Long-term outcomes in young patients with atrioventricular block of unknown aetiology

Research output: Contribution to journalJournal articleResearchpeer-review

  1. HIV infection is associated with thoracic and abdominal aortic aneurysms: a prospective matched cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Oral fluoroquinolones and risk of aortic or mitral regurgitation: a nationwide nested case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Atrial fibrillation and chronic kidney disease

    Research output: Contribution to journalEditorialpeer-review

  4. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Genetic insight into sick sinus syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Dabigatran and The Risk of Staphylococcus Aureus Bacteremia- A Nationwide Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Mid-regional pro-atrial natriuretic peptide levels before and after hemodialysis predict long-term prognosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Danish Citizen´s Preferences for at-home Oropharyngeal/nasal SARS-CoV-2 Specimen Collection

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Data Resource Profile: The Copenhagen Hospital Biobank (CHB)

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Johnni Resdal Dideriksen
  • Morten K Christiansen
  • Jens B Johansen
  • Jens C Nielsen
  • Henning Bundgaard
  • Henrik K Jensen
View graph of relations

AIMS: Atrioventricular block (AVB) of unknown aetiology is rare in the young, and outcome in these patients is unknown. We aimed to assess long-term morbidity and mortality in young patients with AVB of unknown aetiology.

METHODS AND RESULTS: We identified all Danish patients younger than 50 years receiving a first pacemaker due to AVB between January 1996 and December 2015. By reviewing medical records, we included patients with AVB of unknown aetiology. A matched control cohort was established. Follow-up was performed using national registries. The primary outcome was a composite endpoint consisting of death, heart failure hospitalization, ventricular tachyarrhythmia, and cardiac arrest with successful resuscitation. We included 517 patients, and 5170 controls. Median age at first pacemaker implantation was 41.3 years [interquartile range (IQR) 32.7-46.2 years]. After a median follow-up of 9.8 years (IQR 5.7-14.5 years), the primary endpoint had occurred in 14.9% of patients and 3.2% of controls [hazard ratio (HR) 3.8; 95% confidence interval (CI) 2.9-5.1; P < 0.001]. Patients with persistent AVB at time of diagnosis had a higher risk of the primary endpoint (HR 10.6; 95% CI 5.7-20.0; P < 0.001), and risk was highest early in the follow-up period (HR 6.8; 95% CI 4.6-10.0; P < 0.001, during 0-5 years of follow-up).

CONCLUSION: Atrioventricular block of unknown aetiology presenting before the age of 50 years and treated with pacemaker implantation was associated with a three- to four-fold higher rate of the composite endpoint of death or hospitalization for heart failure, ventricular tachyarrhythmia, or cardiac arrest with successful resuscitation. Patients with persistent AVB were at higher risk. These findings warrant improved follow-up strategies for young patients with AVB of unknown aetiology.

Original languageEnglish
JournalEuropean Heart Journal
Volume42
Issue number21
Pages (from-to)2060-2068
Number of pages9
ISSN0195-668X
DOIs
Publication statusPublished - 1 Jun 2021

    Research areas

  • Atrioventricular block, Follow-up, Long-term outcomes, Pacemaker implantation, Unknown aetiology, Young

ID: 62374734