Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adults: The Danish Nurse cohort: The Danish Nurse cohort

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Presence of parabens, phenols and phthalates in paired maternal serum, urine and amniotic fluid

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Acetaminophen metabolism revisited using non-targeted analyses: Implications for human biomonitoring

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long-term exposure to low levels of air pollution and mortality adjusting for road traffic noise: A Danish Nurse Cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Oophorectomy and rate of dementia: a prospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Environmental factors in declining human fertility

    Research output: Contribution to journalReviewResearchpeer-review

  3. The long-term association between bilateral oophorectomy and depression: a prospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Long-term exposure to road traffic noise and all-cause and cause-specific mortality: a Danish Nurse Cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Bilateral oophorectomy and rate of colorectal cancer: A prospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Shuo Liu
  • Youn-Hee Lim
  • Marie Pedersen
  • Jeanette T Jørgensen
  • Heresh Amini
  • Thomas Cole-Hunter
  • Amar J Mehta
  • Rina So
  • Laust H Mortensen
  • Rudi G J Westendorp
  • Steffen Loft
  • Elvira V Bräuner
  • Matthias Ketzel
  • Ole Hertel
  • Jørgen Brandt
  • Steen S Jensen
  • Jesper H Christensen
  • Torben Sigsgaard
  • Camilla Geels
  • Lise M Frohn
  • Maja Brborić
  • Jelena Radonić
  • Maja Turk Sekulic
  • Klaus Bønnelykke
  • Claus Backalarz
  • Mette K Simonsen
  • Zorana J Andersen
View graph of relations

BACKGROUND: Ambient air pollution is likely a risk factor for asthma, and recent evidence suggests the possible relevance of road traffic noise.

OBJECTIVES: We examined the associations of long-term exposure to air pollution and road traffic noise with adult-asthma incidence.

METHODS: We followed 28,731 female nurses (age > 44 years) from the Danish Nurse Cohort, recruited in 1993 and 1999, for first hospital contact for asthma from 1977 until 2015. We estimated residential annual mean concentrations of particulate matter with diameter < 2.5 µm (PM 2.5) since 1990 and nitrogen dioxide (NO 2) since 1970 with the Danish DEHM/UBM/AirGIS modeling system, and road traffic noise (L den) since 1970 with the Nord2000 model. Time-varying Cox regression models were used to associate air pollution and road traffic noise exposure with asthma incidence.

RESULTS: During 18.6 years' mean follow-up, 528 out of 23,093 participants had hospital contact for asthma. The hazard ratios (HR) and 95% confidence intervals for asthma incidence associated with 3-year moving average exposures were 1.29 (1.03, 1.61) per 6.3 µg/m 3 for PM 2.5, 1.16 (1.07, 1.27) per 8.2 µg/m 3 for NO 2, and 1.12 (1.00, 1.25) per 10 dB for L den. The HR for NO 2 remained unchanged after adjustment for either PM 2.5 or L den, while the HRs for PM 2.5 and L den attenuated to unity after adjustment for NO 2.

CONCLUSIONS: Long-term exposure to air pollution was associated with adult-asthma incidence independently of road traffic noise, with NO 2 most relevant. Road traffic noise was not independently associated with adult-asthma incidence.

Original languageEnglish
Article number106464
JournalEnvironment International
Volume152
Pages (from-to)106464
ISSN0160-4120
DOIs
Publication statusPublished - 1 Jul 2021

Bibliographical note

Copyright © 2021. Published by Elsevier Ltd.

    Research areas

  • Adult, Air Pollutants/analysis, Air Pollution/adverse effects, Asthma/epidemiology, Denmark/epidemiology, Environmental Exposure/analysis, Female, Humans, Incidence, Noise, Transportation/adverse effects, Particulate Matter/analysis

ID: 64267691