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Rigshospitalet - a part of Copenhagen University Hospital
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Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness

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    Research output: Contribution to journalJournal articleResearchpeer-review

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    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Metabolic Systems Analysis of Shock-Induced Endotheliopathy (SHINE) in Trauma: A New Research Paradigm

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Junru Wu
  • Anthony Cyr
  • Danielle Gruen
  • Tyler Lovelace
  • Panayiotis Benos
  • Tianmeng Chen
  • Francis Guyette
  • Mark Yazer
  • Brian Daley
  • Richard Miller
  • Brian Harbrecht
  • Jeffrey Claridge
  • Herb Phelan
  • Brian Zuckerbraun
  • Matthew Neal
  • Pär Johansson
  • Jakob Stensballe
  • Rami Namas
  • Yoram Vodovotz
  • Jason Sperry
  • Timothy Billiar
  • PAMPer Study Group
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Alterations in lipid metabolism have the potential to be markers as well as drivers of the pathobiology of acute critical illness. Here, we took advantage of the temporal precision offered by trauma as a common cause of critical illness to identify the dynamic patterns in the circulating lipidome in critically ill humans. The major findings include an early loss of all classes of circulating lipids followed by a delayed and selective lipogenesis in patients destined to remain critically ill. Early in the clinical course, Fresh Frozen Plasma administration led to improved survival in association with preserved lipid levels that related to favorable changes in coagulation and inflammation biomarkers. Late over-representation of phosphatidylethanolamines with critical illness led to the validation of a Lipid Reprogramming Score that was prognostic not only in trauma but also severe COVID-19 patients. Our lipidomic findings provide a new paradigm for the lipid response underlying critical illness.

Original languageEnglish
JournalResearch Square
DOIs
Publication statusPublished - 8 Jan 2021

ID: 61949047