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Less sedentary time is associated with a more favourable glucose-insulin axis in obese pregnant women-a secondary analysis of the DALI study

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Dieberger, AM, Desoye, G, Stolz, E, Hill, DJ, Corcoy, R, Simmons, D, Harreiter, J, Kautzky-Willer, A, Dunne, F, Devlieger, R, Wender-Ozegowska, E, Zawiejska, A, Lapolla, A, Dalfra, MG, Bertolotto, A, Galjaard, S, Adelantado, JM, Jensen, DM, Andersen, L-L, Tanvig, M, Damm, P, Mathiesen, ER, Snoek, FJ, Jelsma, JGM & van Poppel, MNM 2021, 'Less sedentary time is associated with a more favourable glucose-insulin axis in obese pregnant women-a secondary analysis of the DALI study', International journal of obesity (2005), vol. 45, no. 2, pp. 296-307. https://doi.org/10.1038/s41366-020-0639-y

APA

Dieberger, A. M., Desoye, G., Stolz, E., Hill, D. J., Corcoy, R., Simmons, D., Harreiter, J., Kautzky-Willer, A., Dunne, F., Devlieger, R., Wender-Ozegowska, E., Zawiejska, A., Lapolla, A., Dalfra, M. G., Bertolotto, A., Galjaard, S., Adelantado, J. M., Jensen, D. M., Andersen, L-L., ... van Poppel, M. N. M. (2021). Less sedentary time is associated with a more favourable glucose-insulin axis in obese pregnant women-a secondary analysis of the DALI study. International journal of obesity (2005), 45(2), 296-307. https://doi.org/10.1038/s41366-020-0639-y

CBE

Dieberger AM, Desoye G, Stolz E, Hill DJ, Corcoy R, Simmons D, Harreiter J, Kautzky-Willer A, Dunne F, Devlieger R, Wender-Ozegowska E, Zawiejska A, Lapolla A, Dalfra MG, Bertolotto A, Galjaard S, Adelantado JM, Jensen DM, Andersen L-L, Tanvig M, Damm P, Mathiesen ER, Snoek FJ, Jelsma JGM, van Poppel MNM. 2021. Less sedentary time is associated with a more favourable glucose-insulin axis in obese pregnant women-a secondary analysis of the DALI study. International journal of obesity (2005). 45(2):296-307. https://doi.org/10.1038/s41366-020-0639-y

MLA

Vancouver

Author

Dieberger, Anna M ; Desoye, Gernot ; Stolz, Erwin ; Hill, David J ; Corcoy, Rosa ; Simmons, David ; Harreiter, Jürgen ; Kautzky-Willer, Alexandra ; Dunne, Fidelma ; Devlieger, Roland ; Wender-Ozegowska, Ewa ; Zawiejska, Agnieszka ; Lapolla, Annunziata ; Dalfra, Maria Grazia ; Bertolotto, Alessandra ; Galjaard, Sander ; Adelantado, Juan M ; Jensen, Dorte Møller ; Andersen, Lise-Lotte ; Tanvig, Mette ; Damm, Peter ; Mathiesen, Elisabeth Reinhardt ; Snoek, Frank J ; Jelsma, Judith G M ; van Poppel, Mireille N M. / Less sedentary time is associated with a more favourable glucose-insulin axis in obese pregnant women-a secondary analysis of the DALI study. In: International journal of obesity (2005). 2021 ; Vol. 45, No. 2. pp. 296-307.

Bibtex

@article{94a6c084f78542828c7165d5ef6c5537,
title = "Less sedentary time is associated with a more favourable glucose-insulin axis in obese pregnant women-a secondary analysis of the DALI study",
abstract = "BACKGROUND/OBJECTIVES: Obese pregnant women are at high risk of developing gestational diabetes mellitus (GDM), which might be reduced by sufficient physical activity (PA) and reduced sedentary time (ST). We assessed whether PA and ST are longitudinally associated with the glucose-insulin axis in obese pregnant women.SUBJECTS/METHODS: In this secondary analysis of the DALI (vitamin D And Lifestyle Intervention for gestational diabetes mellitus prevention) study, pregnant women, <20 weeks gestation, with a pre-pregnancy body mass index (BMI) ≥ 29 kg/m2, without GDM on entry were included. Time spent in moderate-to-vigorous PA (MVPA) and ST were measured objectively with accelerometers at <20 weeks, 24-28 weeks and 35-37 weeks of gestation. Fasting glucose (mmol/l) and insulin (mU/l), insulin resistance (HOMA-IR) and first-phase and second-phase insulin release (Stumvoll first and second phase) were assessed at the same time. Linear mixed regression models were used to calculate between-participant differences and within-participant changes over time. Analyses were adjusted for gestational age, randomisation, pre-pregnancy BMI, education and age. MVPA, Insulin, HOMA-IR and Stumvoll first and second phase were log-transformed for analyses due to skewness.RESULTS: 232 women were included in the analysis. Concerning differences between participants, more ST was associated with higher fasting glucose (Estimate: 0.008; 95% CI: 0.002, 0.014), fasting insulin (0.011; 0.002, 0.019), HOMA-IR (0.012; 0.004, 0.021) and Stumvoll first and second phase (0.008; 0.001, 0.014 and 0.007; 0.001, 0.014). Participants with more MVPA had lower Stumvoll first and second phase (-0.137; -0.210, -0.064 and -0.133; -0.202, -0.063). Concerning changes over time, an increase in ST during gestation was associated with elevated Stumvoll first and second phase (0.006; 0.000, 0.011).CONCLUSIONS: As the glucose-insulin axis is more strongly associated with ST than MVPA in our obese population, pregnant women could be advised to reduce ST in addition to increasing MVPA. Moreover, our findings suggest that behaviour change interventions aiming at GDM risk reduction should start in early or pre-pregnancy.",
author = "Dieberger, {Anna M} and Gernot Desoye and Erwin Stolz and Hill, {David J} and Rosa Corcoy and David Simmons and J{\"u}rgen Harreiter and Alexandra Kautzky-Willer and Fidelma Dunne and Roland Devlieger and Ewa Wender-Ozegowska and Agnieszka Zawiejska and Annunziata Lapolla and Dalfra, {Maria Grazia} and Alessandra Bertolotto and Sander Galjaard and Adelantado, {Juan M} and Jensen, {Dorte M{\o}ller} and Lise-Lotte Andersen and Mette Tanvig and Peter Damm and Mathiesen, {Elisabeth Reinhardt} and Snoek, {Frank J} and Jelsma, {Judith G M} and {van Poppel}, {Mireille N M}",
year = "2021",
month = feb,
doi = "10.1038/s41366-020-0639-y",
language = "English",
volume = "45",
pages = "296--307",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "2",

}

RIS

TY - JOUR

T1 - Less sedentary time is associated with a more favourable glucose-insulin axis in obese pregnant women-a secondary analysis of the DALI study

AU - Dieberger, Anna M

AU - Desoye, Gernot

AU - Stolz, Erwin

AU - Hill, David J

AU - Corcoy, Rosa

AU - Simmons, David

AU - Harreiter, Jürgen

AU - Kautzky-Willer, Alexandra

AU - Dunne, Fidelma

AU - Devlieger, Roland

AU - Wender-Ozegowska, Ewa

AU - Zawiejska, Agnieszka

AU - Lapolla, Annunziata

AU - Dalfra, Maria Grazia

AU - Bertolotto, Alessandra

AU - Galjaard, Sander

AU - Adelantado, Juan M

AU - Jensen, Dorte Møller

AU - Andersen, Lise-Lotte

AU - Tanvig, Mette

AU - Damm, Peter

AU - Mathiesen, Elisabeth Reinhardt

AU - Snoek, Frank J

AU - Jelsma, Judith G M

AU - van Poppel, Mireille N M

PY - 2021/2

Y1 - 2021/2

N2 - BACKGROUND/OBJECTIVES: Obese pregnant women are at high risk of developing gestational diabetes mellitus (GDM), which might be reduced by sufficient physical activity (PA) and reduced sedentary time (ST). We assessed whether PA and ST are longitudinally associated with the glucose-insulin axis in obese pregnant women.SUBJECTS/METHODS: In this secondary analysis of the DALI (vitamin D And Lifestyle Intervention for gestational diabetes mellitus prevention) study, pregnant women, <20 weeks gestation, with a pre-pregnancy body mass index (BMI) ≥ 29 kg/m2, without GDM on entry were included. Time spent in moderate-to-vigorous PA (MVPA) and ST were measured objectively with accelerometers at <20 weeks, 24-28 weeks and 35-37 weeks of gestation. Fasting glucose (mmol/l) and insulin (mU/l), insulin resistance (HOMA-IR) and first-phase and second-phase insulin release (Stumvoll first and second phase) were assessed at the same time. Linear mixed regression models were used to calculate between-participant differences and within-participant changes over time. Analyses were adjusted for gestational age, randomisation, pre-pregnancy BMI, education and age. MVPA, Insulin, HOMA-IR and Stumvoll first and second phase were log-transformed for analyses due to skewness.RESULTS: 232 women were included in the analysis. Concerning differences between participants, more ST was associated with higher fasting glucose (Estimate: 0.008; 95% CI: 0.002, 0.014), fasting insulin (0.011; 0.002, 0.019), HOMA-IR (0.012; 0.004, 0.021) and Stumvoll first and second phase (0.008; 0.001, 0.014 and 0.007; 0.001, 0.014). Participants with more MVPA had lower Stumvoll first and second phase (-0.137; -0.210, -0.064 and -0.133; -0.202, -0.063). Concerning changes over time, an increase in ST during gestation was associated with elevated Stumvoll first and second phase (0.006; 0.000, 0.011).CONCLUSIONS: As the glucose-insulin axis is more strongly associated with ST than MVPA in our obese population, pregnant women could be advised to reduce ST in addition to increasing MVPA. Moreover, our findings suggest that behaviour change interventions aiming at GDM risk reduction should start in early or pre-pregnancy.

AB - BACKGROUND/OBJECTIVES: Obese pregnant women are at high risk of developing gestational diabetes mellitus (GDM), which might be reduced by sufficient physical activity (PA) and reduced sedentary time (ST). We assessed whether PA and ST are longitudinally associated with the glucose-insulin axis in obese pregnant women.SUBJECTS/METHODS: In this secondary analysis of the DALI (vitamin D And Lifestyle Intervention for gestational diabetes mellitus prevention) study, pregnant women, <20 weeks gestation, with a pre-pregnancy body mass index (BMI) ≥ 29 kg/m2, without GDM on entry were included. Time spent in moderate-to-vigorous PA (MVPA) and ST were measured objectively with accelerometers at <20 weeks, 24-28 weeks and 35-37 weeks of gestation. Fasting glucose (mmol/l) and insulin (mU/l), insulin resistance (HOMA-IR) and first-phase and second-phase insulin release (Stumvoll first and second phase) were assessed at the same time. Linear mixed regression models were used to calculate between-participant differences and within-participant changes over time. Analyses were adjusted for gestational age, randomisation, pre-pregnancy BMI, education and age. MVPA, Insulin, HOMA-IR and Stumvoll first and second phase were log-transformed for analyses due to skewness.RESULTS: 232 women were included in the analysis. Concerning differences between participants, more ST was associated with higher fasting glucose (Estimate: 0.008; 95% CI: 0.002, 0.014), fasting insulin (0.011; 0.002, 0.019), HOMA-IR (0.012; 0.004, 0.021) and Stumvoll first and second phase (0.008; 0.001, 0.014 and 0.007; 0.001, 0.014). Participants with more MVPA had lower Stumvoll first and second phase (-0.137; -0.210, -0.064 and -0.133; -0.202, -0.063). Concerning changes over time, an increase in ST during gestation was associated with elevated Stumvoll first and second phase (0.006; 0.000, 0.011).CONCLUSIONS: As the glucose-insulin axis is more strongly associated with ST than MVPA in our obese population, pregnant women could be advised to reduce ST in addition to increasing MVPA. Moreover, our findings suggest that behaviour change interventions aiming at GDM risk reduction should start in early or pre-pregnancy.

UR - http://www.scopus.com/inward/record.url?scp=85087804760&partnerID=8YFLogxK

U2 - 10.1038/s41366-020-0639-y

DO - 10.1038/s41366-020-0639-y

M3 - Journal article

C2 - 32661292

VL - 45

SP - 296

EP - 307

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 2

ER -

ID: 61381551