Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Leser–Trélat syndrome in malignant mesothelioma and pulmonary adenocarcinoma: is the EGFR pathway part of the syndrome?

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Methodological approach to Microscopic Colitis diagnosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lymphomas of the head and neck region: an update

    Research output: Contribution to journalReviewResearchpeer-review

  3. Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The prevalence of programmed death ligand-1 (PD-L1) expression in non-small cell lung cancer in an unselected, consecutive population

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Oxidized resorbable cellulose (Gelita-cel) causing foreign body reaction in the mediastinum

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The syndrome of Leser–Trélat (LT) is characterized by the sudden appearance of multiple seborrhoeic keratoses (SKs) in association with internal occult malignancy. Usually, the syndrome has been associated with adenocarcinoma, most frequently of the gastrointestinal tract and breast. The pathogenesis is unclear but might be explained by circulating tumor-associated growth factors. We present two thoracic malignancies associated with LT: adenocarcinoma of the lung (ACL) and pleural malignant mesothelioma (MM). Both malignant tumors expressed high levels of epidermal growth factor receptors (EGFR) detected by immunohistochemistry (IHC), with membranous staining on the majority of malignant cells corresponding to maximum IHC scores of 290 and 300, respectively, for the MM and the ACL. SKs revealed a universal membranous staining throughout the entire epithelium with no difference in EGFR expression between the two cases and two controls with no malignant history. By fluorescence in situ hybridization, no amplification of the EGFR gene in malignant tumors as well as in SK lesions was observed. Further investigations are needed to see whether tumor-associated EGFR ligands/EGFR autocrine loops in malignant cells expressing high levels of EGFR protein on the surface might play a role for the development of SKs, as well as for the growth of malignant tumors in LT.

Original languageEnglish
JournalVirchows Archiv : an international journal of pathology
Volume464
Issue number1
Pages (from-to)117-20
Number of pages4
ISSN0945-6317
DOIs
Publication statusPublished - Jan 2014

    Research areas

  • Adenocarcinoma, Aged, Female, Humans, Keratosis, Seborrheic, Lung Neoplasms, Male, Mesothelioma, Paraneoplastic Syndromes, Receptor, Epidermal Growth Factor, Signal Transduction

ID: 44705391