Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Lactobacillus reuteri supplements do not affect salivary IgA or cytokine levels in healthy subjects: A randomized, double-blind, placebo-controlled, cross-over trial

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Saliva in relation to dental erosion before and after radiotherapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Three-dimensional analysis of the pulp cavity on surface models of molar teeth, using X-ray micro-computed tomography

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Nordic Guidelines 2010 for diagnosis and treatment of gastroenteropancreatic neuroendocrine tumours

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ruxolitinib and interferon-α2 combination therapy for patients with polycythemia vera or myelofibrosis: a phase II study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prognostic role of genetic polymorphisms of the interleukin-6 signaling pathway in patients with severe heart failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Thyroid peroxidase antibodies and prospective live birth rate: A cohort study of women with recurrent pregnancy loss

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Expanding the citrullinome of synovial fibrinogen from rheumatoid arthritis patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Mette Rose Jørgensen
  • Mette Kirstine Keller
  • Camilla Kragelund
  • Kristina Hamberg
  • Dan Ericson
  • Claus Henrik Nielsen
  • Svante Twetman
View graph of relations

OBJECTIVES: To evaluate the effect of daily ingestion of probiotic lactobacilli on the levels of secretory IgA (sIgA) and selected cytokines in whole saliva of healthy young adults.

MATERIALS AND METHODS: The study group consisted of 47 healthy adults (18-32 years) who volunteered for a randomized, double-blind, placebo-controlled, cross-over trial after informed consent. During intervention, the subjects ingested two lozenges per day containing two strains of the probiotic bacterium Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) or placebo lozenges. The intervention and wash-out periods were 3 weeks. Saliva samples were collected at baseline, immediately after each intervention period and 3 weeks post-intervention. ELISA was used to measure sIgA and luminex technology was used to measure the interleukins (IL)-1β, IL-6, IL-8 and IL-10. For statistical analyses a mixed ANOVA model was employed to calculate changes in the salivary outcome variables.

RESULTS: Forty-one subjects completed the study and reported a good compliance. No significant differences in the concentrations of salivary sIgA or cytokines were recorded between the L. reuteri and placebo interventions or between baseline and 3 weeks post-intervention levels. No side- or adverse effects were reported.

CONCLUSIONS: Supplementation with two strains of the probiotic L. reuteri did not affect sIgA or cytokine levels in whole saliva in healthy young adults. The results thereby indicate that daily oral supplementation with L. reuteri do not seem to modulate the salivary oral immune response in healthy young subjects (ClinicalTrials.gov NCT02017886).

Original languageEnglish
JournalActa Odontologica Scandinavica
Volume74
Issue number5
Pages (from-to)399-404
Number of pages6
ISSN0001-6357
DOIs
Publication statusPublished - Jul 2016

    Research areas

  • Adolescent, Adult, Cross-Over Studies, Dietary Supplements, Double-Blind Method, Female, Follow-Up Studies, Humans, Immunoglobulin A, Secretory, Interleukin-10, Interleukin-1beta, Interleukin-6, Interleukin-8, Interleukins, Lactobacillus reuteri, Male, Placebos, Probiotics, Saliva, Salivary Proteins and Peptides, Young Adult, Comparative Study, Journal Article, Randomized Controlled Trial

ID: 49808057