Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Ley, SH, Chavarro, JE, Li, M, Bao, W, Hinkle, SN, Wander, PL, Rich-Edwards, J, Olsen, S, Vaag, A, Damm, P, Grunnet, LG, Mills, JL, Hu, FB & Zhang, C 2020, 'Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus' Diabetes Care, vol. 43, no. 4, dc192237, pp. 793-798. https://doi.org/10.2337/dc19-2237

APA

Ley, S. H., Chavarro, J. E., Li, M., Bao, W., Hinkle, S. N., Wander, P. L., ... Zhang, C. (2020). Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus. Diabetes Care, 43(4), 793-798. [dc192237]. https://doi.org/10.2337/dc19-2237

CBE

Ley SH, Chavarro JE, Li M, Bao W, Hinkle SN, Wander PL, Rich-Edwards J, Olsen S, Vaag A, Damm P, Grunnet LG, Mills JL, Hu FB, Zhang C. 2020. Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus. Diabetes Care. 43(4):793-798. https://doi.org/10.2337/dc19-2237

MLA

Vancouver

Author

Ley, Sylvia H ; Chavarro, Jorge E ; Li, Mengying ; Bao, Wei ; Hinkle, Stefanie N ; Wander, Pandora L ; Rich-Edwards, Janet ; Olsen, Sjurdur ; Vaag, Allan ; Damm, Peter ; Grunnet, Louise G ; Mills, James L ; Hu, Frank B ; Zhang, Cuilin. / Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus. In: Diabetes Care. 2020 ; Vol. 43, No. 4. pp. 793-798.

Bibtex

@article{d6fc85f2da3d4a2290a5a325c9e409fc,
title = "Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus",
abstract = "OBJECTIVE: We examined the association of lactation duration with incident type 2 diabetes among women with a history of gestational diabetes mellitus (GDM).RESEARCH DESIGN AND METHODS: We monitored 4,372 women with a history of GDM participating in the Nurses' Health Study II for incident type 2 diabetes over 25 years up to 2017. Lactation history was obtained through follow-up questionnaires to calculate lactation duration. Follow-up blood samples were collected from a subset of these women at median age of 58 years through the Diabetes & Women's Health Study.RESULTS: We documented 873 incident cases of type 2 diabetes during 87,411 person-years of follow-up. Longer duration of lactation was associated with lower risk of type 2 diabetes for both total lactation (hazard ratio 1.05 [95{\%} CI 0.83-1.34] for up to 6 months, 0.91 [0.72-1.16] for 6-12 months, 0.85 [0.67-1.06] for 12-24 months, and 0.73 [0.57-0.93] for >24 months, compared with 0 months; P-trend = 0.003) and exclusive breastfeeding (P-trend = 0.002) after adjustment for age, ethnicity, family history of diabetes, parity, age at first birth, smoking, diet quality, physical activity, and prepregnancy BMI. Longer duration of lactation was also associated with lower HbA1c, fasting plasma insulin, and C-peptide concentrations among women without type 2 diabetes at follow-up (all adjusted P-trend ≤0.04).CONCLUSIONS: Longer duration of lactation is associated with a lower risk of type 2 diabetes and a favorable glucose metabolic biomarker profile among women with a history of GDM. The underlying mechanisms and impact on diabetes complications, morbidity, and mortality remain to be determined.",
author = "Ley, {Sylvia H} and Chavarro, {Jorge E} and Mengying Li and Wei Bao and Hinkle, {Stefanie N} and Wander, {Pandora L} and Janet Rich-Edwards and Sjurdur Olsen and Allan Vaag and Peter Damm and Grunnet, {Louise G} and Mills, {James L} and Hu, {Frank B} and Cuilin Zhang",
note = "{\circledC} 2020 by the American Diabetes Association.",
year = "2020",
month = "4",
doi = "10.2337/dc19-2237",
language = "English",
volume = "43",
pages = "793--798",
journal = "International Journal of MS Care",
issn = "1935-5548",
publisher = "American Diabetes Association",
number = "4",

}

RIS

TY - JOUR

T1 - Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus

AU - Ley, Sylvia H

AU - Chavarro, Jorge E

AU - Li, Mengying

AU - Bao, Wei

AU - Hinkle, Stefanie N

AU - Wander, Pandora L

AU - Rich-Edwards, Janet

AU - Olsen, Sjurdur

AU - Vaag, Allan

AU - Damm, Peter

AU - Grunnet, Louise G

AU - Mills, James L

AU - Hu, Frank B

AU - Zhang, Cuilin

N1 - © 2020 by the American Diabetes Association.

PY - 2020/4

Y1 - 2020/4

N2 - OBJECTIVE: We examined the association of lactation duration with incident type 2 diabetes among women with a history of gestational diabetes mellitus (GDM).RESEARCH DESIGN AND METHODS: We monitored 4,372 women with a history of GDM participating in the Nurses' Health Study II for incident type 2 diabetes over 25 years up to 2017. Lactation history was obtained through follow-up questionnaires to calculate lactation duration. Follow-up blood samples were collected from a subset of these women at median age of 58 years through the Diabetes & Women's Health Study.RESULTS: We documented 873 incident cases of type 2 diabetes during 87,411 person-years of follow-up. Longer duration of lactation was associated with lower risk of type 2 diabetes for both total lactation (hazard ratio 1.05 [95% CI 0.83-1.34] for up to 6 months, 0.91 [0.72-1.16] for 6-12 months, 0.85 [0.67-1.06] for 12-24 months, and 0.73 [0.57-0.93] for >24 months, compared with 0 months; P-trend = 0.003) and exclusive breastfeeding (P-trend = 0.002) after adjustment for age, ethnicity, family history of diabetes, parity, age at first birth, smoking, diet quality, physical activity, and prepregnancy BMI. Longer duration of lactation was also associated with lower HbA1c, fasting plasma insulin, and C-peptide concentrations among women without type 2 diabetes at follow-up (all adjusted P-trend ≤0.04).CONCLUSIONS: Longer duration of lactation is associated with a lower risk of type 2 diabetes and a favorable glucose metabolic biomarker profile among women with a history of GDM. The underlying mechanisms and impact on diabetes complications, morbidity, and mortality remain to be determined.

AB - OBJECTIVE: We examined the association of lactation duration with incident type 2 diabetes among women with a history of gestational diabetes mellitus (GDM).RESEARCH DESIGN AND METHODS: We monitored 4,372 women with a history of GDM participating in the Nurses' Health Study II for incident type 2 diabetes over 25 years up to 2017. Lactation history was obtained through follow-up questionnaires to calculate lactation duration. Follow-up blood samples were collected from a subset of these women at median age of 58 years through the Diabetes & Women's Health Study.RESULTS: We documented 873 incident cases of type 2 diabetes during 87,411 person-years of follow-up. Longer duration of lactation was associated with lower risk of type 2 diabetes for both total lactation (hazard ratio 1.05 [95% CI 0.83-1.34] for up to 6 months, 0.91 [0.72-1.16] for 6-12 months, 0.85 [0.67-1.06] for 12-24 months, and 0.73 [0.57-0.93] for >24 months, compared with 0 months; P-trend = 0.003) and exclusive breastfeeding (P-trend = 0.002) after adjustment for age, ethnicity, family history of diabetes, parity, age at first birth, smoking, diet quality, physical activity, and prepregnancy BMI. Longer duration of lactation was also associated with lower HbA1c, fasting plasma insulin, and C-peptide concentrations among women without type 2 diabetes at follow-up (all adjusted P-trend ≤0.04).CONCLUSIONS: Longer duration of lactation is associated with a lower risk of type 2 diabetes and a favorable glucose metabolic biomarker profile among women with a history of GDM. The underlying mechanisms and impact on diabetes complications, morbidity, and mortality remain to be determined.

U2 - 10.2337/dc19-2237

DO - 10.2337/dc19-2237

M3 - Journal article

VL - 43

SP - 793

EP - 798

JO - International Journal of MS Care

JF - International Journal of MS Care

SN - 1935-5548

IS - 4

M1 - dc192237

ER -

ID: 59294297