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Kidney failure related to broad-spectrum antibiotics in critically ill patients: secondary end point results from a 1200 patient randomised trial

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Harvard

Jensen, J-US, Hein, L, Lundgren, B, Bestle, MH, Mohr, T, Andersen, MH, Thornberg, KJ, Løken, J, Steensen, M, Fox, Z, Tousi, H, Søe-Jensen, P, Lauritsen, AØ, Strange, DG, Reiter, N, Thormar, K, Fjeldborg, PC, Larsen, KM, Drenck, N-E, Johansen, ME, Nielsen, LR, Kjær, J, Grarup, J, Lundgren, JD, The Procalcitonin And Survival Study (PASS) Group & Andersen, CØ 2012, 'Kidney failure related to broad-spectrum antibiotics in critically ill patients: secondary end point results from a 1200 patient randomised trial' BMJ Open, vol. 2, no. 2, pp. e000635. https://doi.org/10.1136/bmjopen-2011-000635

APA

CBE

Jensen J-US, Hein L, Lundgren B, Bestle MH, Mohr T, Andersen MH, Thornberg KJ, Løken J, Steensen M, Fox Z, Tousi H, Søe-Jensen P, Lauritsen AØ, Strange DG, Reiter N, Thormar K, Fjeldborg PC, Larsen KM, Drenck N-E, Johansen ME, Nielsen LR, Kjær J, Grarup J, Lundgren JD, The Procalcitonin And Survival Study (PASS) Group, Andersen CØ. 2012. Kidney failure related to broad-spectrum antibiotics in critically ill patients: secondary end point results from a 1200 patient randomised trial. BMJ Open. 2(2):e000635. https://doi.org/10.1136/bmjopen-2011-000635

MLA

Vancouver

Author

Jensen, Jens-Ulrik Stæhr ; Hein, Lars ; Lundgren, Bettina ; Bestle, Morten Heiberg ; Mohr, Thomas ; Andersen, Mads Holmen ; Thornberg, Klaus Julius ; Løken, Jesper ; Steensen, Morten ; Fox, Zoë ; Tousi, Hamid ; Søe-Jensen, Peter ; Lauritsen, Anne Øberg ; Strange, Ditte Gry ; Reiter, Nanna ; Thormar, Katrin ; Fjeldborg, Paul Christian ; Larsen, Kim Michael ; Drenck, Niels-Erik ; Johansen, Maria Egede ; Nielsen, Lene Ryom ; Kjær, Jesper ; Grarup, Jesper ; Lundgren, Jens D ; The Procalcitonin And Survival Study (PASS) Group ; Andersen, Christian Østergaard. / Kidney failure related to broad-spectrum antibiotics in critically ill patients : secondary end point results from a 1200 patient randomised trial. In: BMJ Open. 2012 ; Vol. 2, No. 2. pp. e000635.

Bibtex

@article{5bef51ddf41b4fc6b229b972d63ba698,
title = "Kidney failure related to broad-spectrum antibiotics in critically ill patients: secondary end point results from a 1200 patient randomised trial",
abstract = "OBJECTIVES: To explore whether a strategy of more intensive antibiotic therapy leads to emergence or prolongation of renal failure in intensive care patients. DESIGN: Secondary analysis from a randomised antibiotic strategy trial (the Procalcitonin And Survival Study). The randomised arms were conserved from the primary trial for the main analysis. SETTING: Nine mixed surgical/medical intensive care units across Denmark. PARTICIPANTS: 1200 adult intensive care patients, 18+ years, expected to stay +24 h. Exclusion criteria: bilirubin >40 mg/dl, triglycerides >1000 mg/dl, increased risk from blood sampling, pregnant/breast feeding and psychiatric patients. INTERVENTIONS: Patients were randomised to guideline-based therapy ('standard-exposure' arm) or to guideline-based therapy supplemented with antibiotic escalation whenever procalcitonin increased on daily measurements ('high-exposure' arm). MAIN OUTCOME MEASURES: Primary end point: estimated glomerular filtration rate (eGFR)",
author = "Jensen, {Jens-Ulrik St{\ae}hr} and Lars Hein and Bettina Lundgren and Bestle, {Morten Heiberg} and Thomas Mohr and Andersen, {Mads Holmen} and Thornberg, {Klaus Julius} and Jesper L{\o}ken and Morten Steensen and Zo{\"e} Fox and Hamid Tousi and Peter S{\o}e-Jensen and Lauritsen, {Anne {\O}berg} and Strange, {Ditte Gry} and Nanna Reiter and Katrin Thormar and Fjeldborg, {Paul Christian} and Larsen, {Kim Michael} and Niels-Erik Drenck and Johansen, {Maria Egede} and Nielsen, {Lene Ryom} and Jesper Kj{\ae}r and Jesper Grarup and Lundgren, {Jens D} and {The Procalcitonin And Survival Study (PASS) Group} and Andersen, {Christian {\O}stergaard}",
year = "2012",
doi = "10.1136/bmjopen-2011-000635",
language = "English",
volume = "2",
pages = "e000635",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Kidney failure related to broad-spectrum antibiotics in critically ill patients

T2 - secondary end point results from a 1200 patient randomised trial

AU - Jensen, Jens-Ulrik Stæhr

AU - Hein, Lars

AU - Lundgren, Bettina

AU - Bestle, Morten Heiberg

AU - Mohr, Thomas

AU - Andersen, Mads Holmen

AU - Thornberg, Klaus Julius

AU - Løken, Jesper

AU - Steensen, Morten

AU - Fox, Zoë

AU - Tousi, Hamid

AU - Søe-Jensen, Peter

AU - Lauritsen, Anne Øberg

AU - Strange, Ditte Gry

AU - Reiter, Nanna

AU - Thormar, Katrin

AU - Fjeldborg, Paul Christian

AU - Larsen, Kim Michael

AU - Drenck, Niels-Erik

AU - Johansen, Maria Egede

AU - Nielsen, Lene Ryom

AU - Kjær, Jesper

AU - Grarup, Jesper

AU - Lundgren, Jens D

AU - The Procalcitonin And Survival Study (PASS) Group

AU - Andersen, Christian Østergaard

PY - 2012

Y1 - 2012

N2 - OBJECTIVES: To explore whether a strategy of more intensive antibiotic therapy leads to emergence or prolongation of renal failure in intensive care patients. DESIGN: Secondary analysis from a randomised antibiotic strategy trial (the Procalcitonin And Survival Study). The randomised arms were conserved from the primary trial for the main analysis. SETTING: Nine mixed surgical/medical intensive care units across Denmark. PARTICIPANTS: 1200 adult intensive care patients, 18+ years, expected to stay +24 h. Exclusion criteria: bilirubin >40 mg/dl, triglycerides >1000 mg/dl, increased risk from blood sampling, pregnant/breast feeding and psychiatric patients. INTERVENTIONS: Patients were randomised to guideline-based therapy ('standard-exposure' arm) or to guideline-based therapy supplemented with antibiotic escalation whenever procalcitonin increased on daily measurements ('high-exposure' arm). MAIN OUTCOME MEASURES: Primary end point: estimated glomerular filtration rate (eGFR)

AB - OBJECTIVES: To explore whether a strategy of more intensive antibiotic therapy leads to emergence or prolongation of renal failure in intensive care patients. DESIGN: Secondary analysis from a randomised antibiotic strategy trial (the Procalcitonin And Survival Study). The randomised arms were conserved from the primary trial for the main analysis. SETTING: Nine mixed surgical/medical intensive care units across Denmark. PARTICIPANTS: 1200 adult intensive care patients, 18+ years, expected to stay +24 h. Exclusion criteria: bilirubin >40 mg/dl, triglycerides >1000 mg/dl, increased risk from blood sampling, pregnant/breast feeding and psychiatric patients. INTERVENTIONS: Patients were randomised to guideline-based therapy ('standard-exposure' arm) or to guideline-based therapy supplemented with antibiotic escalation whenever procalcitonin increased on daily measurements ('high-exposure' arm). MAIN OUTCOME MEASURES: Primary end point: estimated glomerular filtration rate (eGFR)

U2 - 10.1136/bmjopen-2011-000635

DO - 10.1136/bmjopen-2011-000635

M3 - Journal article

VL - 2

SP - e000635

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 2

ER -

ID: 34802515