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Is clinical heterogeneity the foremost prominent threat to the validity of meta-analyses?

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Systematic review methodology with meta-analyses have long been regarded as one of the highest forms of research methodology and a cornerstone in many clinical guidelines. A common criticism of this methodology is the handling of the clinical and/or statistical heterogeneity which arises when pooling heterogenous data from different trials, settings and interventions.

Original languageEnglish
JournalActa Anaesthesiologica Scandinavica
Volume65
Issue number7
Pages (from-to)863-864
Number of pages2
ISSN0001-5172
DOIs
Publication statusPublished - Aug 2021

ID: 65654447