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Involvement of adenosine signaling pathway in migraine pathophysiology: A systematic review of clinical studies

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  1. Effect of KATP channel blocker glibenclamide on PACAP38-induced headache and hemodynamic

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Provoked versus spontaneous migraine attacks: pathophysiological similarities and differences

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  3. One-quarter of individuals with weekly headache have never consulted a medical doctor: a Danish nationwide cross-sectional survey

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  4. Efficacy and safety of eptinezumab in patients with migraine and self-reported aura: Post hoc analysis of PROMISE-1 and PROMISE-2

    Research output: Contribution to journalJournal articleResearchpeer-review

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OBJECTIVE: To systematically review clinical studies investigating the involvement of adenosine and its receptors in migraine pathophysiology.

BACKGROUND: Adenosine is a purinergic signaling molecule, clinically used in cardiac imaging during stress tests. Headache is a frequent adverse event after intravenous adenosine administration. Migraine headache relief is reported after intake of adenosine receptor antagonist, caffeine. These findings suggest a possible involvement of adenosine signaling in migraine pathophysiology and its potential as a drug target.

METHODS: A search through PubMed and EMBASE was undertaken for clinical studies investigating the role of adenosine and its receptors in migraine, published until September 2021.

RESULTS: A total of 2510 studies were screened by title and abstract. Of these, seven clinical studies were included. The main findings were that adenosine infusion induced headache, and plasma adenosine levels were elevated during ictal compared to interictal periods in migraine patients.

CONCLUSION: The present systematic review emphasizes a potentially important role of adenosine signaling in migraine pathogenesis. Further randomized and placebo-controlled clinical investigations applying adenosine receptors modulators in migraine patients are needed to further understand the adenosine involvement in migraine.

Original languageEnglish
JournalCephalalgia : an international journal of headache
Volume42
Issue number8
Pages (from-to)781-792
Number of pages12
ISSN0333-1024
DOIs
Publication statusPublished - Jul 2022

    Research areas

  • adenosine receptor, Headache, humans, migraine

ID: 75773817