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Rigshospitalet - a part of Copenhagen University Hospital
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Intravenous saline administration in patients with severe acquired brain injury and orthostatic intolerance for tilt-table mobilization

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PRIMARY OBJECTIVE: This study aimed to investigate the effect of intravenous saline administration on orthostatic hypotension (OH) during head up tilt (HUT) and the change in the renin-angiotensin-aldosterone system before and after HUT in patients with severe acquired brain injury (ABI).

RESEARCH DESIGN: The study is designed as an observational study.

METHODS AND PROCEDURES: Fourteen patients with ABI, low level of consciousness and OH were monitored before, during and after HUT with non-invasive beat-to-beat blood pressure measurement, and transcranial Doppler determination of middle cerebral artery blood flow velocity. Blood samples were collected before and after two HUT sessions separated by 1 hour and saline was administered in between.

MAIN OUTCOMES AND RESULTS: Patients' ability to stand upright did not change after saline administration due to OH. The patients showed signs of reduced cerebral autoregulation at both HUT sessions. The patients had a significant lower level of renin and angiotensin II but not aldosterone.

CONCLUSIONS: Patients with severe ABI and OH demonstrate no improvement in standing time with reduced plasma renin and angiotensin II after two HUT sessions and 1 hour fluid administration. Research focusing on the ability to retain fluid after bed rest is warranted.

Original languageEnglish
JournalBrain Injury
Volume32
Issue number2
Pages (from-to)252-256
Number of pages5
ISSN0269-9052
DOIs
Publication statusPublished - 2018

    Research areas

  • Journal Article

ID: 52225158