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Rigshospitalet - a part of Copenhagen University Hospital
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Intratumor heterogeneity of PD-L1 expression in head and neck squamous cell carcinoma

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  1. Plasma total cell-free DNA is a prognostic biomarker of overall survival in metastatic solid tumour patients

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  2. Risk of cardiovascular events in men treated for prostate cancer compared with prostate cancer-free men

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  3. Breast cancer mortality in synchronous bilateral breast cancer patients

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  1. High nodal FDG uptake increases risk of distant metastasis in patients with oropharyngeal squamous cell carcinoma

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  2. Mortality and admission to intensive care units after febrile neutropenia in patients with cancer

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  3. Use of nonaspirin nonsteroidal anti-inflammatory drugs and risk of head and neck cancer: A nationwide case-control study

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  4. Electrochemotherapy in the head and neck area: an addition to the treatment armamentarium

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  5. Improved Survival of Children, Adolescents, and Young Adults With Head and Neck Soft Tissue Sarcomas in Denmark

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Intratumor heterogeneity may contribute to the ambiguous clinical results on PD-L1 status as a predictor for immunotherapy response in patients with HNSCC. This decreases the utility of PD-L1 expression from single tumour biopsies as a predictive biomarker. In this prospective study, intratumor heterogeneity of PD-L1 expression in HNSCC was investigated with both Tumour Proportion Score (TPS) and Combined Positive Score (CPS). Thirty-three whole surgical specimens from 28 patients with HNSCC were included. PD-L1 expression in six random core biopsies from each surgical specimen was used to assess the concordance between multiple biopsies and the negative predictive value of a single negative core biopsy. With 1% cut off, 36% of the specimens were concordant with TPS and 52% with CPS. With a 50% cut-off value the concordance was 70% with TPS and 55% with CPS. Defining a tumour as positive if just a single-one of the biopsies was positive, the negative predictive value (NPV) of a single negative core biopsy was 38.9 and 0% (1% cut off), and 79.9% and 62.8% (50% cut off) for TPS and CPS, respectively. In conclusion, PD-L1 positivity varies markedly within the tumour, both with TPS and CPS, challenging the utility of this biomarker.

Original languageEnglish
JournalBritish Journal of Cancer
Volume120
Issue number10
Pages (from-to)1003-1006
Number of pages4
ISSN0007-0920
DOIs
Publication statusPublished - May 2019

ID: 57751970