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Rigshospitalet - a part of Copenhagen University Hospital
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Intestinal metaplasia is a precursor lesion for sinonasal intestinal type adenocarcinoma: genomic investigation of a case proving this hypothesis

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Intestinal metaplasia (IM) of the sinonasal mucosa is a putative precursor lesion of sinonasal intestinal type adenocarcinoma (sITAC), a carcinoma associated with wood-dust exposure(1-5). In this article, we compare genomic alterations in matched IM and sITAC to substantiate this connection. Case presentation: A 68-year-old man with a history of wood-dust exposure and one-month bloody nasal secretion was seen at his local hospital. A biopsy demonstrated poorly differentiated carcinoma with neuroendocrine features. Fine needle aspiration (FNA) from a slightly enlarged cervical lymph node was without metastatic tumor cells. On MRI, the tumor measured 38x33x37mm; no signs of lymph-node pathology were seen (T2N0M0). A tertiary center performed endoscopic surgery; perioperative frozen sections showed sITAC (margins were macroscopically free).

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume130
Issue number1
Pages (from-to)53-56
Number of pages4
ISSN0903-4641
DOIs
Publication statusPublished - Jan 2022

Bibliographical note

This article is protected by copyright. All rights reserved.

    Research areas

  • DNA-mutations, genomics, metaplasia, Sinonasal cancer, Sinonasal intestinal-type adenocarcinoma

ID: 69026066