Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Interhemispheric differences of fMRI responses to visual stimuli in patients with side-fixed migraine aura

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Subclinical depressive symptoms during late midlife and structural brain alterations: A longitudinal study of Danish men born in 1953

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The chronobiology of migraine: a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  3. PEARL study protocol: a real-world study of fremanezumab effectiveness in patients with chronic or episodic migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Opening of BKCa channels causes migraine attacks: a new downstream target for the treatment of migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Erenumab prevents the occurrence of migraine attacks and not just migraine days: Post-hoc analyses of a phase III study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Migraine sufferers with aura often report photosensitivity and visual discomfort outside of attacks and many consider bright or flickering light an attack-precipitating factor. The nature of this visual hypersensitivity and its relation to the underlying pathophysiology of the migraine aura is unknown. Using fMRI measurements during visual stimulation we examined the visual cortical responsiveness of patients with migraine with aura. We applied a within-patient design by assessing functional interhemispheric differences in patients consistently experiencing visual aura in the same visual hemifield. We recruited 20 patients with frequent side-fixed visual aura attacks (≥90% of auras occurring in the same visual hemifield) and 20 age and sex matched healthy controls and compared the fMRI blood oxygenation level dependent (BOLD) responses to visual stimulation between symptomatic and asymptomatic hemispheres during the interictal phase and between migraine patients and controls. BOLD responses were selectively increased in the symptomatic hemispheres. This was found in the inferior parietal lobule (P = 0.002), the inferior frontal gyrus (P = 0.003), and the superior parietal lobule (P = 0.017). The affected cortical areas comprise a visually driven functional network involved in oculomotor control, guidance of movement, motion perception, visual attention, and visual spatial memory. The patients also had significantly increased response in the same cortical areas when compared to controls (P
Original languageEnglish
JournalHuman Brain Mapping
Volume35
Issue number6
Pages (from-to)2714-2723
Number of pages9
ISSN1065-9471
DOIs
Publication statusPublished - Jun 2014

ID: 39400261