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Increased short- and long-term mortality following infections in dementia: a nationwide registry-based cohort study

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BACKGROUND AND PURPOSE: Mortality following infections in dementia has not yet been comprehensively explored. The aim of this cohort study was to investigate the short- and long-term mortality following infections in dementia.

METHODS: Follow-up was from 1 January 2000 or the 65-year birthday until death, immigration, or 31 December 2015. Exposure was incident dementia and a first infection. The outcome was all-cause mortality. Mortality rate ratios (MRRs) were calculated using Poisson regression in 4 exposure groups (dementia yes/no, infection yes/no) by sex, infection site, and time since infection.

RESULTS: 1,496,436 people were followed with 12,739,135 person-years. MRR in dementia/infection was 6.52 (95% confidence interval: 6.43-6.60) and was increased for infections of all sites. Increased mortality was short term (30 days) and long term (10 years).

CONCLUSIONS: Increased mortality in people with dementia identifies them as a particularly vulnerable group that needs clinical attention.

Original languageEnglish
Article number2
JournalEuropean Journal of Neurology
Volume28
Issue number2
Pages (from-to)411-420
Number of pages10
ISSN1351-5101
DOIs
Publication statusPublished - Feb 2021

    Research areas

  • dementia, epidemiology, infection, mortality, registry-based study, based study, registry&#8208

ID: 61553386