Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
E-pub ahead of print

Inclusion, delivery, assessment, and outcomes in longitudinal research on sleep disturbance and agitation in TBI-rehabilitation: lessons learned and future considerations

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Predictors of disability in adolescents and young adults with acquired brain injury after the acute phase

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The Family Needs Questionnaire-Revised: a Rasch analysis of measurement properties in the chronic phase after traumatic brain injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Communication with patients in post-traumatic confusional state: Perception of rehabilitation staff

    Research output: Contribution to journalReviewResearchpeer-review

  4. Family needs at one and two years after severe traumatic brain injury: a prospective study of changes and predictors

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Post-traumatic stress disorder attributed to traumatic brain injury in children - a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  1. Cognitive training for prevention of cognitive impairment in adult intensive care unit (ICU) patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Does rocking motion calm delirious patients in ICU? A multicentre randomised clinical trial protocol (RockingICU)

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Iatrogenic withdrawal syndrome frequently occurs in paediatric intensive care without algorithm for tapering of analgosedation

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Socioeconomic inequality in telephone triage on triage response, hospitalization and 30-day mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: This article presents some issues for consideration before scaling from a pilot study to a larger investigation in longitudinal observational studies of traumatic brain injury (TBI) rehabilitation.

MATERIALS AND METHODS: We present a case to discuss protocol improvements in longitudinal TBI-rehabilitation studies. The case was a pilot study conducted at two university hospitals in Denmark investigating 1-year outcomes related to sleep disturbance and agitation during neurointensive care. We included patients with moderate and severe TBI determined by the Glasgow Coma Scale, sleep disturbance was assessed using actigraphy, and agitation was assessed using the Agitated Behavior Scale.

RESULTS: Patients (n = 29) were more severely ill and had poorer six-month outcomes in Eastern vs. Western Denmark. Recovery was similar at one-year follow-up. Protocol improvements were needed in relation to inclusion criteria, intervention delivery, patient assessment, and follow-up outcomes.

CONCLUSION: In TBI-rehabilitation studies, we suggest adding the severity of disease score to the initial GCS score and a delirium detection score to the ABS score. Actigraphy should not be used during deep sedation. Established procedures should be in place along all stages of the study protocol, including preparation and periodic assessment of study nurses to optimize data quality.

Original languageEnglish
JournalBrain Injury
Pages (from-to)1-8
Number of pages8
ISSN0269-9052
DOIs
Publication statusE-pub ahead of print - 22 Sep 2021

    Research areas

  • Agitation, outcomes research, rehabilitation, sleep disturbance, traumatic brain injury

ID: 67788977