Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Incidence and survival of oropharyngeal cancer in Denmark: a nation-wide, population-based study from 1980 to 2014

Research output: Contribution to journalJournal articleResearchpeer-review

  1. European cancer rehabilitation and survivorship, 2018: one of a kind

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Exercise-mediated improvement of depression in patients with gastro-esophageal junction cancer is linked to kynurenine metabolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. MyHealth: specialist nurse-led follow-up in breast cancer. A randomized controlled trial - development and feasibility

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Dynamic soft tissue changes in the orbit after a blowout fracture

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. PET/CT prior to salvage surgery in recurrent head and neck squamous cell carcinoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Reliability and validity of The Danish pediatric voice handicap index

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Oropharyngeal carcinomas (OPCs) constitute a significant and increasing proportion of head and neck carcinomas and are an important global cause of morbidity and mortality. The purpose of this study was to determine trends in incidence and survival in OPC in the Danish population from 1980 to 2014.

METHODS: This study included all patients registered in the nationwide Danish Cancer Registry over the period 1980-2014. The age-adjusted incidence rates (AAIR) per 100,000, annual percentage change (APC) and average annual percent change (AAPC) were evaluated. Five-year relative survival (RS) was calculated with Cox regression analyses in relation to gender, anatomical location and histology.

RESULTS: A total of 6555 patients (69% male) were included, with a median age at diagnosis of 60 years. The AAIR of patients with OPC increased from 0.815 per 100,000 in 1980 to 4.51 per 100,000 in 2014 with an AAPC of 5.3. The 5-year RS increased significantly from 33.1% over the period 1980-1984 to 58.5% (25.4% points) over the period 2010-2014. With no significant difference stratified for gender. Tumors located at the palatine tonsils (n = 3333) and salivary gland OPC (n = 90) had significantly better survival compared with other sub-locations and histology subtypes. In the APC model the birth cohort effect rate ratio increased until 1925 and then decreased until 1935 from which point it increased in the last cohorts.

CONCLUSIONS: In this population-based study, we observed a significant increase in the incidence of OPCs and in the RS for OPC. We also identified a profound birth cohort effect on the incidence.

Original languageEnglish
JournalActa oncologica (Stockholm, Sweden)
Volume57
Issue number2
Pages (from-to)269-275
Number of pages7
ISSN0284-186X
DOIs
Publication statusPublished - Feb 2018

    Research areas

  • Journal Article

ID: 52600299