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Implementation of treatment recommendations for chronic hepatitis B in patients attending specialized hospital care in Denmark - a region wide study

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Bollerup, Signe ; Hallager, Sofie ; Baek, Ole ; Krarup, Henrik ; Madsen, Lone Galmstrup ; Thielsen, Peter ; Balslev, Ulla ; Mens, Helene ; Barfod, Toke ; Rye Clausen, Mette ; Hobolth, Lise ; Gerstoft, Jan ; Weis, Nina. / Implementation of treatment recommendations for chronic hepatitis B in patients attending specialized hospital care in Denmark - a region wide study. In: Scandinavian Journal of Gastroenterology. 2020 ; Vol. 55, No. 7. pp. 843-847.

Bibtex

@article{5bbf073313bc4b8f8ec8b4cc08881677,
title = "Implementation of treatment recommendations for chronic hepatitis B in patients attending specialized hospital care in Denmark - a region wide study",
abstract = "Objective: To evaluate implementation of national guideline recommendations on treatment initiation for chronic hepatitis B (CHB) in Denmark.Methods: Using DANHEP, a nationwide cohort of chronic hepatitis B and C patients attending specialized hospital care in Denmark, we performed a descriptive cohort study from January 2002 through December 2017. We identified patients with CHB in 3 of 5 Danish regions, with at least two hospital/outpatient clinic visits during the study period.Results: We identified 990 CHB patients who remained untreated throughout the study period, and 265 who initiated treatment. At their last visit 952/990 (96{\%}, 95{\%} CI 95-97) untreated patients did not meet current national criteria for treatment initiation while 198/265 (75{\%}, 95{\%} CI 69-80) who initiated treatment met the national criteria. Overall, 198/236 (84{\%}, 95{\%} CI 79-88) who met national treatment criteria, initiated treatment.Conclusion: The majority of CHB patients received care in line with national guideline recommendations for treatment initiation. We found that only few patients eligible for treatment remained untreated. However, a fourth of patients who received treatment were not eligible according to national guidelines.",
keywords = "adherence, antiviral therapy, Chronic hepatitis B, Denmark, guideline implementation, recommendations",
author = "Signe Bollerup and Sofie Hallager and Ole Baek and Henrik Krarup and Madsen, {Lone Galmstrup} and Peter Thielsen and Ulla Balslev and Helene Mens and Toke Barfod and {Rye Clausen}, Mette and Lise Hobolth and Jan Gerstoft and Nina Weis",
year = "2020",
month = "7",
doi = "10.1080/00365521.2020.1779803",
language = "English",
volume = "55",
pages = "843--847",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis",
number = "7",

}

RIS

TY - JOUR

T1 - Implementation of treatment recommendations for chronic hepatitis B in patients attending specialized hospital care in Denmark - a region wide study

AU - Bollerup, Signe

AU - Hallager, Sofie

AU - Baek, Ole

AU - Krarup, Henrik

AU - Madsen, Lone Galmstrup

AU - Thielsen, Peter

AU - Balslev, Ulla

AU - Mens, Helene

AU - Barfod, Toke

AU - Rye Clausen, Mette

AU - Hobolth, Lise

AU - Gerstoft, Jan

AU - Weis, Nina

PY - 2020/7

Y1 - 2020/7

N2 - Objective: To evaluate implementation of national guideline recommendations on treatment initiation for chronic hepatitis B (CHB) in Denmark.Methods: Using DANHEP, a nationwide cohort of chronic hepatitis B and C patients attending specialized hospital care in Denmark, we performed a descriptive cohort study from January 2002 through December 2017. We identified patients with CHB in 3 of 5 Danish regions, with at least two hospital/outpatient clinic visits during the study period.Results: We identified 990 CHB patients who remained untreated throughout the study period, and 265 who initiated treatment. At their last visit 952/990 (96%, 95% CI 95-97) untreated patients did not meet current national criteria for treatment initiation while 198/265 (75%, 95% CI 69-80) who initiated treatment met the national criteria. Overall, 198/236 (84%, 95% CI 79-88) who met national treatment criteria, initiated treatment.Conclusion: The majority of CHB patients received care in line with national guideline recommendations for treatment initiation. We found that only few patients eligible for treatment remained untreated. However, a fourth of patients who received treatment were not eligible according to national guidelines.

AB - Objective: To evaluate implementation of national guideline recommendations on treatment initiation for chronic hepatitis B (CHB) in Denmark.Methods: Using DANHEP, a nationwide cohort of chronic hepatitis B and C patients attending specialized hospital care in Denmark, we performed a descriptive cohort study from January 2002 through December 2017. We identified patients with CHB in 3 of 5 Danish regions, with at least two hospital/outpatient clinic visits during the study period.Results: We identified 990 CHB patients who remained untreated throughout the study period, and 265 who initiated treatment. At their last visit 952/990 (96%, 95% CI 95-97) untreated patients did not meet current national criteria for treatment initiation while 198/265 (75%, 95% CI 69-80) who initiated treatment met the national criteria. Overall, 198/236 (84%, 95% CI 79-88) who met national treatment criteria, initiated treatment.Conclusion: The majority of CHB patients received care in line with national guideline recommendations for treatment initiation. We found that only few patients eligible for treatment remained untreated. However, a fourth of patients who received treatment were not eligible according to national guidelines.

KW - adherence

KW - antiviral therapy

KW - Chronic hepatitis B

KW - Denmark

KW - guideline implementation

KW - recommendations

UR - http://www.scopus.com/inward/record.url?scp=85087291572&partnerID=8YFLogxK

U2 - 10.1080/00365521.2020.1779803

DO - 10.1080/00365521.2020.1779803

M3 - Journal article

VL - 55

SP - 843

EP - 847

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 7

ER -

ID: 60131420