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Rigshospitalet - a part of Copenhagen University Hospital
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Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma

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TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas.

Original languageEnglish
Article numbere12773
JournalNeuropathology and Applied Neurobiology
Volume48
Issue number3
Pages (from-to)e12773
ISSN0305-1846
DOIs
Publication statusPublished - Apr 2022

ID: 69209777