Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Impact of type 1 diabetes and glycemic control on fetal aneuploidy biochemical markers

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Antidepressant use in pregnancy and severe cardiac malformations: Danish register-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Crown-rump length measurement error: impact on assessment of growth

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Severe foetal anaemia caused by undetected alloimmunisation in a RhD-positive pregnant woman

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Kongenitte portosystemiske shunter, diagnose og behandling af en multisystemisk sygdom hos børn

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations
Objective. To determine the influence of type 1 diabetes mellitus (T1DM) on the first trimester serum markers of fetal aneuploidy; pregnancy-associated plasma protein-A (PAPP-A) and free beta subunit of human chorionic gonadotropin (free β-hCG) and to evaluate the influence of glycemic control on these parameters in the pregnant diabetic women. Design. Retrospective study. Setting. Data were extracted from electronic obstetric and laboratory databases at two Danish University Hospitals. Population. Based on 36 415 pregnancies without T1DM (non-T1DM) and 331 pregnancies with T1DM; β-hCG and PAPP-A were obtained at 8+0 to 14+2 gestational weeks. Methods. Medians for PAPP-A and free β-hCG were generated and multiple of the normal gestation-specific median (MoM) values were calculated for each separate pregnancy. After adjustment for maternal weight, ethnicity and smoking status, MoM values were compared across the T1DM and non-T1DM groups, respectively. Additionally, the relationship between PAPP-A MoM and HgbA1C was examined in 348 T1DM pregnancies by Spearman's rank correlation. Main outcome measures. Difference in biochemical marker levels between T1DM and non-T1DM. Results. PAPP-A was 0.86 MoM in T1DM pregnancies and 1.01 MoM in non-T1DM pregnancies, p <0.0001. Conversely, free β-hCG was not altered in T1DM pregnancies (T1DM 0.99 MoM, non-T1DM 0.98 MoM; p=0.14). There was a significant inverse correlation between HgbA1C and PAPP-A (rho=-0.12, p=0.02). Conclusions. In T1DM pregnancies, PAPP-A MoM values were lower than in non-T1DM pregnancies. This suggests that correction should be considered in first trimester biochemical screening for fetal aneuploidy in T1DM women.
Original languageEnglish
JournalActa Obstetricia et Gynecologica Scandinavica
Volume91
Issue number1
Pages (from-to)57-61
Number of pages5
ISSN0001-6349
DOIs
Publication statusPublished - 2012

ID: 33125404