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Rigshospitalet - a part of Copenhagen University Hospital
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Imaging of treatment response to the combination of carboplatin and paclitaxel in human ovarian cancer xenograft tumors in mice using FDG and FLT PET

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  1. Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked?

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  2. Dyslipidemia at diagnosis of childhood acute lymphoblastic leukemia

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  3. Newborn body composition after maternal bariatric surgery

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  1. 123I-MIBG for detection of subacute doxorubicin-induced cardiotoxicity in patients with malignant lymphoma

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  2. Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes

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  3. Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals

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A combination of carboplatin and paclitaxel is often used as first line chemotherapy for treatment of ovarian cancer. Therefore the use of imaging biomarkers early after initiation of treatment to determine treatment sensitivity would be valuable in order to identify responders from non-responders. In this study we describe the non-invasive PET imaging of glucose uptake and cell proliferation using 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) and 3'-deoxy-3'-[(18)F]fluorothymidine (FLT) for early assessment of treatment response in a pre-clinical mouse model of human ovarian cancer treated with carboplatin and paclitaxel.
Original languageEnglish
JournalP L o S One
Volume8
Issue number12
Pages (from-to)e85126
ISSN1932-6203
DOIs
Publication statusPublished - 2013

ID: 43158645