Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Reproducibility of histologic prognostic parameters for mantle cell lymphoma: cytology, Ki67, p53 and SOX11

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Methodological approach to Microscopic Colitis diagnosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Lymphomas of the head and neck region: an update

    Research output: Contribution to journalReviewpeer-review

  4. Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Finasteride interferes with prostaglandin-induced CatSper-signalling in human sperm

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The calcium-sensing receptor is essential for calcium and bicarbonate sensitivity in human spermatozoa

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Establishment of a novel human fetal adrenal culture model that supports de novo and manipulated steroidogenesis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. UV filters in matched seminal fluid-, urine-, and serum samples from young men

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Free testosterone and cardiometabolic parameters in men: comparison of algorithms

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Testicular germ-cell tumours of young adults are derived from a pre-invasive intratubular lesion, carcinoma in situ (CIS). In a recent genome-wide gene expression screening using cDNA microarrays, we found PDPN over-expressed in CIS compared to normal adult testis. PDPN encodes podoplanin (Aggrus, human gp36, T1A-2), a transmembrane glycoprotein expressed in lymphatic endothelium and various solid tumours. To examine a potential role for PDPN in testicular neoplasms and during testicular development, we investigated its expression pattern during the development of human testis and in a series of testicular CIS, gonadoblastoma and overt germ-cell tumours. We established by RT-PCR and by immunohistochemistry with a gp36 antibody that PDPN mRNA and the protein product were expressed in testes with germ-cell neoplasms but not in the normal adult testis. We also found gp36 expression in early foetal gonocytes and immature Sertoli cells, similar to the expression pattern of M2A antigen, a previously identified marker for CIS and seminoma. This reinforced our previous proposal that M2A (D2-40) antigen was identical to gp36 (podoplanin, Aggrus, T1A-2). Our findings also suggest that podoplanin has a function in developing testis, most likely at the level of cell-cell interactions among pre-meiotic germ cells and immature Sertoli cells.
Original languageEnglish
JournalVirchows Archiv : an international journal of pathology
Volume449
Issue number2
Pages (from-to)200-6
Number of pages7
ISSN0945-6317
DOIs
Publication statusPublished - Aug 2006

    Research areas

  • Adolescent, Adult, Antigens, Neoplasm, Carcinoma in Situ, Child, Child, Preschool, Humans, Infant, Male, Membrane Glycoproteins, Middle Aged, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms, Testis

ID: 41681227