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Hypoxic challenge test applied to healthy children: influence of body positions and exertion on pulse oximetric saturation

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BACKGROUND: Commercial aircraft are pressurised to ~2438 m (8000 ft) above sea level that equates breathing 15% oxygen at sea level. A preflight hypoxic challenge test (HCT) is therefore recommended for children with cystic fibrosis or other chronic lung diseases and inflight oxygen is advised if pulse oximetric saturation (SpO2) decreases <90%.

OBJECTIVE: Study responses to a modified HCT, encompassing various body positions and light physical activity, reflecting relevant activities of children during flight, with a view to challenge the evidence of the current cut-off.

METHODS: Oxygenation, heart rate and ventilation were observed in 34 healthy schoolchildren (17 boys) undergoing a modified HCT, alternating between breathing room air and 15% oxygen in nitrogen while seated, supine, standing and walking at 3 km/h and 5 km/h.

RESULTS: Nadir SpO2 <90%, median (range), occurred in 9 subjects sitting, 89% (78-89%); 6 supine, 88.5% (87-89%); 9 standing, 89% (85-89%); 23 walking 3 km/h, 87% (74-89%); and 21 walking 5 km/h, 86% (74-89%). Total time <90% for these subjects in seconds was 20 (10-80) sitting, 30 (10-190) supine, 50 (10-150) standing, 80 (10-260) walking 3 km/h and 125 (10-300) walking 5 km/h. Light exercise in general led to lower SpO2: 91% (77-96%), p<0.0001.

CONCLUSIONS: A modified HCT led to moments of desaturation below 90% in various body positions at rest and during light physical activity in healthy schoolchildren. It is questionable whether the international recommended cut-off of 90% for children with chronic lung disease reflects clinical oxygen dependence during flights.

Original languageEnglish
JournalArchives of Disease in Childhood
Volume98
Issue number8
Pages (from-to)602-6
Number of pages5
ISSN0003-9888
DOIs
Publication statusPublished - Aug 2013

    Research areas

  • Adolescent, Air Ambulances, Altitude, Child, Chronic Disease, Cross-Over Studies, Cross-Sectional Studies, Exercise, Female, Humans, Lung Diseases, Male, Oximetry, Oxygen, Posture, Prospective Studies, Questionnaires, Spirometry

ID: 43625418