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Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected 2006-2012

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@article{935384dcbb5d48019354fac76bd36058,
title = "Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected 2006-2012",
abstract = "Several non-persistent industrial chemicals have shown endocrine disrupting effects in animal studies and are suspected to be involved in human reproductive disorders. Among the non-persistent chemicals which have been discussed intensively during the past years are phthalates, bisphenol A, triclosan and parabens because of their anti-androgenic and/or estrogenic effects.Phthalates are plastizers used in numerous of industrial products. Bisphenol-A is the main component of polycarbonate plastics and epoxy resins. Parabens and triclosan are anti-microbial preservatives and other phenols such as benzophenone-3 act as UV-screener, while chloro-phenols and phenyl phenols are used as pesticides and fungicides in agriculture.In spite of the widespread use of industrial chemicals, knowledge about exposure sources and human biomonitoring studies among different segments of the population are very limited. In Denmark we have no survey programs for non-persistent environmental chemicals as it is known in some countries like USA (NHANES) and Germany (GerES). However, we have analyzed the excretion of seven parabens, nine phenols and metabolites of eight different phthalates in urine samples collected during the past 6 years from four Danish cohorts. Here we present biomonitoring data in more than 3600 Danish children, adolescents, young men and pregnant women from the general population. Our study shows that nearly all Danes were exposed to the six most common phthalates, to bisphenol A, triclosan and benzophenon-3 and to at least two of the parabens. The exposure to other non-persistent chemicals was also widespread. Our data indicates decreasing excretion of two common phthalates (DnBP and DEHP) over time.",
author = "Hanne Frederiksen and Jensen, {Tina Kold} and Niels J{\o}rgensen and {Boye Kyhl}, Henriette and Steffen Husby and Skakkebaek, {Niels Erik} and Main, {Katharina M} and Anders Juul and Anna-Maria Andersson",
year = "2014",
month = "1",
day = "6",
doi = "10.1530/REP-13-0522",
language = "English",
volume = "147",
pages = "555--565",
journal = "Reproduction",
issn = "1470-1626",
publisher = "BioScientifica Ltd",

}

RIS

TY - JOUR

T1 - Human urinary excretion of non-persistent environmental chemicals

T2 - an overview of Danish data collected 2006-2012

AU - Frederiksen, Hanne

AU - Jensen, Tina Kold

AU - Jørgensen, Niels

AU - Boye Kyhl, Henriette

AU - Husby, Steffen

AU - Skakkebaek, Niels Erik

AU - Main, Katharina M

AU - Juul, Anders

AU - Andersson, Anna-Maria

PY - 2014/1/6

Y1 - 2014/1/6

N2 - Several non-persistent industrial chemicals have shown endocrine disrupting effects in animal studies and are suspected to be involved in human reproductive disorders. Among the non-persistent chemicals which have been discussed intensively during the past years are phthalates, bisphenol A, triclosan and parabens because of their anti-androgenic and/or estrogenic effects.Phthalates are plastizers used in numerous of industrial products. Bisphenol-A is the main component of polycarbonate plastics and epoxy resins. Parabens and triclosan are anti-microbial preservatives and other phenols such as benzophenone-3 act as UV-screener, while chloro-phenols and phenyl phenols are used as pesticides and fungicides in agriculture.In spite of the widespread use of industrial chemicals, knowledge about exposure sources and human biomonitoring studies among different segments of the population are very limited. In Denmark we have no survey programs for non-persistent environmental chemicals as it is known in some countries like USA (NHANES) and Germany (GerES). However, we have analyzed the excretion of seven parabens, nine phenols and metabolites of eight different phthalates in urine samples collected during the past 6 years from four Danish cohorts. Here we present biomonitoring data in more than 3600 Danish children, adolescents, young men and pregnant women from the general population. Our study shows that nearly all Danes were exposed to the six most common phthalates, to bisphenol A, triclosan and benzophenon-3 and to at least two of the parabens. The exposure to other non-persistent chemicals was also widespread. Our data indicates decreasing excretion of two common phthalates (DnBP and DEHP) over time.

AB - Several non-persistent industrial chemicals have shown endocrine disrupting effects in animal studies and are suspected to be involved in human reproductive disorders. Among the non-persistent chemicals which have been discussed intensively during the past years are phthalates, bisphenol A, triclosan and parabens because of their anti-androgenic and/or estrogenic effects.Phthalates are plastizers used in numerous of industrial products. Bisphenol-A is the main component of polycarbonate plastics and epoxy resins. Parabens and triclosan are anti-microbial preservatives and other phenols such as benzophenone-3 act as UV-screener, while chloro-phenols and phenyl phenols are used as pesticides and fungicides in agriculture.In spite of the widespread use of industrial chemicals, knowledge about exposure sources and human biomonitoring studies among different segments of the population are very limited. In Denmark we have no survey programs for non-persistent environmental chemicals as it is known in some countries like USA (NHANES) and Germany (GerES). However, we have analyzed the excretion of seven parabens, nine phenols and metabolites of eight different phthalates in urine samples collected during the past 6 years from four Danish cohorts. Here we present biomonitoring data in more than 3600 Danish children, adolescents, young men and pregnant women from the general population. Our study shows that nearly all Danes were exposed to the six most common phthalates, to bisphenol A, triclosan and benzophenon-3 and to at least two of the parabens. The exposure to other non-persistent chemicals was also widespread. Our data indicates decreasing excretion of two common phthalates (DnBP and DEHP) over time.

U2 - 10.1530/REP-13-0522

DO - 10.1530/REP-13-0522

M3 - Journal article

VL - 147

SP - 555

EP - 565

JO - Reproduction

JF - Reproduction

SN - 1470-1626

ER -

ID: 42809501