Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Human papillomavirus and squamous cell carcinoma of the urinary bladder: DaBlaCa-10 study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. DaPeCa-4: outcome in penile cancer patients with N3 disease due to extra nodal extension treated with surgery and chemo-irradiation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Oncological outcomes of radical nephroureterectomy for upper urinary tract urothelial neoplasia in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Educational level and first-time PSA testing in general practice

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Left sided flank pain due to Bochdalek hernia with intrathoracic kidney

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The prognostic impact of incidental prostate cancer following radical cystoprostatectomy: a nationwide analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. AZGP1 Protein Expression in Hormone-Naïve Advanced Prostate Cancer Treated with Primary Androgen Deprivation Therapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Genotype-phenotype associations in PPGLs in 59 patients with variants in SDHX genes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Oncological outcomes of radical nephroureterectomy for upper urinary tract urothelial neoplasia in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Predictive value of AZGP1 following radical prostatectomy for prostate cancer: a cohort study and meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Kit Riegels Jørgensen
  • Søren Høyer
  • Jakob Kristian Jakobsen
  • Thor Knak Jensen
  • Niels Marcussen
  • Gitte Wrist Lam
  • Thomas Hasselager
  • Peter Ole Thind
  • Birgitte Grønkær Toft
  • Torben Steiniche
  • Jørgen Bjerggaard Jensen
View graph of relations

OBJECTIVE: To evaluate a potential association between Human Papillomavirus (H.P.V.) and squamous cell carcinoma (S.C.C.) urinary bladder cancer (B.C.). Furthermore, the relation between p16INK4a, H.P.V. and B.C. was examined.

PATIENTS AND METHODS: Patients were included and divided into three groups based on the histological diagnosis of B.C.

SPECIMENS: An extensive exclusion was performed, including accepted casual risk factors for S.C.C. B.C., such as long-term use of catheters, cystolithiasis and Schistosoma hematobium infection. A total of 100 patients were included: 50 with pure S.C.C., 25 with urothelial carcinomas (U.C.) and 25 with squamous differentiation of U.C. (Sq.D.). The patients were operated at one of four major Danish hospitals in the period January 2005 to December 2016. Clinical information was collected from the medical records. Presence of H.P.V. was analyzed using the INNO-LiPA H.P.V. Genotyping Extra II. p16INK4a was analyzed using immunohistochemical (I.H.C.) staining. A p-value <0.05 was considered statistically significant.

RESULTS: An overall H.P.V. prevalence of 12/100 (12%) was observed. H.P.V. was demonstrated in 9/50 (18%) of the S.C.C.

PATIENTS: Overall, p16INK4a over-expression was observed in 52/100 (52%) patients. However, concomitant H.P.V. positivity and p16INK4a over-expression were observed in only 4/100 (4%) patients.

CONCLUSION: The presence of H.P.V. in one fifth of patients with S.C.C. B.C. was demonstrated. H.P.V. infection could have a significant association with S.C.C. B.C. without other known casual risk factors for S.C.C. B.C.

Original languageEnglish
JournalScandinavian Journal of Urology
Volume52
Issue number5-6
Pages (from-to)371-376
ISSN2168-1805
DOIs
Publication statusPublished - 2019

    Research areas

  • Urinary bladder cancer, human papillomavirus, p16ink4a, squamous cell carcinoma, Carcinoma, Squamous Cell/epidemiology, Carcinoma, Transitional Cell/epidemiology, Humans, Middle Aged, Risk Factors, Genotype, Male, Papillomavirus Infections/epidemiology, Cyclin-Dependent Kinase Inhibitor p16/metabolism, Denmark/epidemiology, Adult, Female, Papillomaviridae, Aged, Retrospective Studies, Urinary Bladder Neoplasms/epidemiology

ID: 56245976