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Household Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 and Association With Coronavirus Disease 2019 Severity: a Danish nationwide cohort study

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  • Marcella M Broccia
  • Victoria Elizabeth V E de Knegt
  • Elisabeth Helen Anna E H A Mills
  • Amalie Lykkemark A L Møller
  • Filip F Gnesin
  • Thea K T K Fischer
  • Nertila N Zylyftari
  • Stig Nikolaj S N Blomberg
  • Mikkel Porsborg M P Andersen
  • Morten M Schou
  • Emil E Fosbøl
  • Kristian K Kragholm
  • Helle Collatz H C Christensen
  • Laura Bech L B Polcwiartek
  • Matthew M Phelps
  • Lars L Køber
  • Christian C Torp-Pedersen
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BACKGROUND: Households are high-risk settings for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severity of coronavirus disease 2019 (COVID-19) is likely associated with the infectious dose of SARS-CoV-2 exposure. We therefore aimed to assess the association between SARS-CoV-2 exposure within households and COVID-19 severity.

METHODS: We performed a Danish, nationwide, register-based, cohort study including laboratory-confirmed SARS-CoV-2-infected individuals from 22 February 2020 to 6 October 2020. Household exposure to SARS-CoV-2 was defined as having 1 individual test positive for SARS-CoV-2 within the household. Cox proportional hazards models were used to estimate the association between "critical COVID-19" within and between households with and without secondary cases.

RESULTS: From 15 063 multiperson households, 19 773 SARS-CoV-2-positive individuals were included; 11 632 were categorized as index cases without any secondary household cases; 3431 as index cases with secondary cases, that is, 22.8% of multiperson households; and 4710 as secondary cases. Critical COVID-19 occurred in 2.9% of index cases living with no secondary cases, 4.9% of index cases with secondary cases, and 1.3% of secondary cases. The adjusted hazard ratio for critical COVID-19 among index cases vs secondary cases within the same household was 2.50 (95% confidence interval [CI], 1.88-3.34), 2.27 (95% CI, 1.77-2.93) for index cases in households with no secondary cases vs secondary cases, and 1.1 (95% CI, .93-1.30) for index cases with secondary cases vs index cases without secondary cases.

CONCLUSIONS: We found no increased hazard ratio of critical COVID-19 among household members of infected SARS-CoV-2 index cases.

Original languageEnglish
Article numberciab340
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Issue number1
Pages (from-to)1-7
Number of pages7
Publication statusPublished - 7 Jan 2022

    Research areas

  • COVID-19, Cohort Studies, Denmark/epidemiology, Family Characteristics, Humans, SARS-CoV-2, transmission, viral load, death, corona, infectious dose

ID: 65156784