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Rigshospitalet - a part of Copenhagen University Hospital
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High dose intravenous iron, mineral homeostasis and intact FGF23 in normal and uremic rats

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High iron load might have a number of toxic effects in the organism. Recently intravenous (iv) iron has been proposed to induce elevation of fibroblast growth factor 23 (FGF23), hypophosphatemia and osteomalacia in iron deficient subjects. High levels of FGF23 are associated with increased mortality in the chronic kidney disease (CKD) population. CKD patients are often treated with iv iron therapy in order to maintain iron stores and erythropoietin responsiveness, also in the case of not being iron depleted. Therefore, the effect of a single high iv dose of two different iron preparations, iron isomaltoside 1000 (IIM) and ferric carboxymaltose (FCM), on plasma levels of FGF23 and phosphate was examined in normal and uremic iron repleted rats.
Original languageEnglish
JournalB M C Nephrology
Volume14
Issue number1
Pages (from-to)281
Number of pages8
ISSN1471-2369
DOIs
Publication statusPublished - 2013

ID: 42333152