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Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy

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  • Nille B Wulff
  • Susanne O Dalton
  • Irene Wessel
  • Beatriz Arenaz Búa
  • Helena Löfhede
  • Eva Hammerlid
  • Trille K Kjaer
  • Christian Godballe
  • Thomas Kjaergaard
  • Preben Homøe
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OBJECTIVES/HYPOTHESIS: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects.

STUDY DESIGN: Cross-sectional study.

METHODS: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires.

RESULTS: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score.

CONCLUSION: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL.

LEVEL OF EVIDENCE: 3 Laryngoscope, 132:980-988, 2022.

Original languageEnglish
JournalThe Laryngoscope
Volume132
Issue number5
Pages (from-to)980-988
Number of pages9
ISSN0023-852X
DOIs
Publication statusPublished - May 2022

Bibliographical note

© 2021 The American Laryngological, Rhinological and Otological Society, Inc.

    Research areas

  • depression, dysphagia, health-related quality of life, Total laryngectomy, voice problems

ID: 67831125