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Headache at onset of first-ever ischemic stroke: Clinical characteristics and predictors

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Harvard

Lebedeva, ER, Ushenin, AV, Gurary, NM, Tsypushkina, TS, Gilev, DV, Kislyak, NV & Olesen, J 2021, 'Headache at onset of first-ever ischemic stroke: Clinical characteristics and predictors', European Journal of Neurology, vol. 28, no. 3, pp. 852-860. https://doi.org/10.1111/ene.14684

APA

Lebedeva, E. R., Ushenin, A. V., Gurary, N. M., Tsypushkina, T. S., Gilev, D. V., Kislyak, N. V., & Olesen, J. (2021). Headache at onset of first-ever ischemic stroke: Clinical characteristics and predictors. European Journal of Neurology, 28(3), 852-860. https://doi.org/10.1111/ene.14684

CBE

MLA

Vancouver

Lebedeva ER, Ushenin AV, Gurary NM, Tsypushkina TS, Gilev DV, Kislyak NV et al. Headache at onset of first-ever ischemic stroke: Clinical characteristics and predictors. European Journal of Neurology. 2021 Mar;28(3):852-860. https://doi.org/10.1111/ene.14684

Author

Lebedeva, Elena R ; Ushenin, Anton V ; Gurary, Natalia M ; Tsypushkina, Tatiana S ; Gilev, Denis V ; Kislyak, Nadezda V ; Olesen, Jes. / Headache at onset of first-ever ischemic stroke : Clinical characteristics and predictors. In: European Journal of Neurology. 2021 ; Vol. 28, No. 3. pp. 852-860.

Bibtex

@article{2783ba6c89b04e3c9da203716d8a943a,
title = "Headache at onset of first-ever ischemic stroke: Clinical characteristics and predictors",
abstract = "No studies have prospectively investigated headache at onset of first-ever ischemic stroke along with a large concurrent control group. Our aims were to answer two important questions: (i) Are headaches at stroke onset causally related to the stroke, and what are their typical clinical characteristics? (ii) What etiology of stroke is associated with these headaches? The study population consisted of 550 patients (mean age = 63.1, 54% males) with first-ever ischemic stroke and 192 control patients (mean age = 58.7, 36% males) admitted to the emergency room without any acute neurological deficits or serious disorders. All data were collected prospectively, using a standardized case-report form during face-to-face interviews by neurologists. Headache at onset of ischemic stroke was present in 82 (14.9%) of 550 patients. More than half (56%) had a new type of headache (mainly migraine-like) simultaneously with stroke onset, and 36% had headache with altered characteristics (mainly tension-type-like headache). Headaches were associated with cardioembolism (p = 0.002, odds ratio [OR] = 2.4, 95% confidence interval [CI] = 1.4-4.1), posterior circulation stroke (p = 0.01, OR = 2.0, 95% CI = 1.2-3.5), infarcts >15 mm (p = 0.03, 95% CI = 1.1-2.7), infarcts of the cerebellum (p = 0.02, OR = 2.3, 95% CI = 1.1-4.8), good neurological status (p = 0.01, OR = 2.5, 95% CI = 1.2-4.9), and low frequency of large-artery atherosclerosis (p = 0.004, OR = 0.4, 95% CI = 0.2-0.8). At stroke onset, headache of a new type and headache with altered characteristics were related to ischemic stroke. They were associated with certain etiologies of stroke.",
keywords = "headache, headache attributed to stroke, headache in stroke, migraine, secondary headache, stroke, stroke, headache in stroke",
author = "Lebedeva, {Elena R} and Ushenin, {Anton V} and Gurary, {Natalia M} and Tsypushkina, {Tatiana S} and Gilev, {Denis V} and Kislyak, {Nadezda V} and Jes Olesen",
note = "{\textcopyright} 2020 European Academy of Neurology.",
year = "2021",
month = mar,
doi = "10.1111/ene.14684",
language = "English",
volume = "28",
pages = "852--860",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Headache at onset of first-ever ischemic stroke

T2 - Clinical characteristics and predictors

AU - Lebedeva, Elena R

AU - Ushenin, Anton V

AU - Gurary, Natalia M

AU - Tsypushkina, Tatiana S

AU - Gilev, Denis V

AU - Kislyak, Nadezda V

AU - Olesen, Jes

N1 - © 2020 European Academy of Neurology.

PY - 2021/3

Y1 - 2021/3

N2 - No studies have prospectively investigated headache at onset of first-ever ischemic stroke along with a large concurrent control group. Our aims were to answer two important questions: (i) Are headaches at stroke onset causally related to the stroke, and what are their typical clinical characteristics? (ii) What etiology of stroke is associated with these headaches? The study population consisted of 550 patients (mean age = 63.1, 54% males) with first-ever ischemic stroke and 192 control patients (mean age = 58.7, 36% males) admitted to the emergency room without any acute neurological deficits or serious disorders. All data were collected prospectively, using a standardized case-report form during face-to-face interviews by neurologists. Headache at onset of ischemic stroke was present in 82 (14.9%) of 550 patients. More than half (56%) had a new type of headache (mainly migraine-like) simultaneously with stroke onset, and 36% had headache with altered characteristics (mainly tension-type-like headache). Headaches were associated with cardioembolism (p = 0.002, odds ratio [OR] = 2.4, 95% confidence interval [CI] = 1.4-4.1), posterior circulation stroke (p = 0.01, OR = 2.0, 95% CI = 1.2-3.5), infarcts >15 mm (p = 0.03, 95% CI = 1.1-2.7), infarcts of the cerebellum (p = 0.02, OR = 2.3, 95% CI = 1.1-4.8), good neurological status (p = 0.01, OR = 2.5, 95% CI = 1.2-4.9), and low frequency of large-artery atherosclerosis (p = 0.004, OR = 0.4, 95% CI = 0.2-0.8). At stroke onset, headache of a new type and headache with altered characteristics were related to ischemic stroke. They were associated with certain etiologies of stroke.

AB - No studies have prospectively investigated headache at onset of first-ever ischemic stroke along with a large concurrent control group. Our aims were to answer two important questions: (i) Are headaches at stroke onset causally related to the stroke, and what are their typical clinical characteristics? (ii) What etiology of stroke is associated with these headaches? The study population consisted of 550 patients (mean age = 63.1, 54% males) with first-ever ischemic stroke and 192 control patients (mean age = 58.7, 36% males) admitted to the emergency room without any acute neurological deficits or serious disorders. All data were collected prospectively, using a standardized case-report form during face-to-face interviews by neurologists. Headache at onset of ischemic stroke was present in 82 (14.9%) of 550 patients. More than half (56%) had a new type of headache (mainly migraine-like) simultaneously with stroke onset, and 36% had headache with altered characteristics (mainly tension-type-like headache). Headaches were associated with cardioembolism (p = 0.002, odds ratio [OR] = 2.4, 95% confidence interval [CI] = 1.4-4.1), posterior circulation stroke (p = 0.01, OR = 2.0, 95% CI = 1.2-3.5), infarcts >15 mm (p = 0.03, 95% CI = 1.1-2.7), infarcts of the cerebellum (p = 0.02, OR = 2.3, 95% CI = 1.1-4.8), good neurological status (p = 0.01, OR = 2.5, 95% CI = 1.2-4.9), and low frequency of large-artery atherosclerosis (p = 0.004, OR = 0.4, 95% CI = 0.2-0.8). At stroke onset, headache of a new type and headache with altered characteristics were related to ischemic stroke. They were associated with certain etiologies of stroke.

KW - headache

KW - headache attributed to stroke

KW - headache in stroke

KW - migraine

KW - secondary headache

KW - stroke

KW - stroke, headache in stroke

UR - http://www.scopus.com/inward/record.url?scp=85099061533&partnerID=8YFLogxK

U2 - 10.1111/ene.14684

DO - 10.1111/ene.14684

M3 - Journal article

C2 - 33331100

VL - 28

SP - 852

EP - 860

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 3

ER -

ID: 61821070