Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Mitochondrial dysfunction induced by variation in the non-coding genome - A proposed workflow to improve diagnostics

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Muscle contractility of leg muscles in patients with mitochondrial myopathies

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Mitochondrial dysfunction underlying outer retinal diseases

    Research output: Contribution to journalReviewResearchpeer-review

  1. Phenotypic Spectrum of α-Dystroglycanopathies Associated With the c.919T>a Variant in the FKRP Gene in Humans and Mice

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Data from the European registry for patients with McArdle disease and other muscle glycogenoses (EUROMAC)

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Creation and implementation of a European registry for patients with McArdle disease and other muscle glycogenoses (EUROMAC registry)

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Bimagrumab vs Optimized Standard of Care for Treatment of Sarcopenia in Community-Dwelling Older Adults: A Randomized Clinical Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Vacuoles, Often Containing Glycogen, Are a Consistent Finding in Hypokalemic Periodic Paralysis

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: We investigated if Growth and Differentiation Factor 15 (GDF-15) can be used as a biomarker to distinguish patients with mitochondrial myopathy from patients with other myopathies.

METHODS: Serum GDF-15 was measured in 28 patients with mitochondrial disease, 24 with metabolic myopathies, 27 with muscular dystrophy and 21 healthy controls.

RESULTS AND CONCLUSIONS: Our findings indicate that elevated GDF-15 can distinguish patients with mitochondrial myopathy from other myopathies, including metabolic myopathies. This suggests that increases in GDF-15 is specific to respiratory chain dysfunction rather than general metabolic dysfunction or muscle defect.

Original languageEnglish
JournalMitochondrion
Volume50
Pages (from-to)35-41
Number of pages7
ISSN1567-7249
DOIs
Publication statusPublished - Jan 2020

    Research areas

  • Exercise, Growth and differentiation factor 15, Metabolic myopathy, Mitochondrial myopathy, Muscular dystrophy

ID: 58350438