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Rigshospitalet - a part of Copenhagen University Hospital
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Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells’ Type 1 Interferon Response

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  2. Periocular necrotizing soft tissue infection in Greater Copenhagen

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  • Nadia Keller
  • Janine Woytschak
  • Lukas Erwin Martin Heeb
  • Ewerton Marques Maggio
  • Srikanth Mairpady Shambat
  • Johanna Snäll
  • Ole Hyldegaard
  • Onur Boyman
  • Anna Norrby-Teglund
  • Annelies Sophie Zinkernagel
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Group A Streptococcus causes severe invasive infections, including necrotizing fasciitis. The expression of an array of virulence factors targeting specific host immune functions impedes successful bacterial clearance. The virulence factor streptococcal DNase Sda1 was previously shown to interfere with the entrapment of bacteria through neutrophil extracellular traps and TLR9 signaling. In this study, we showed that plasmacytoid dendritic cells are recruited to the infected tissue during group A streptococcal necrotizing fasciitis. We found that the streptococcal DNase Sda1 impairs plasmacytoid dendritic cell recruitment by reducing IFN-1 levels at the site of infection. We found that streptococcal DNase Sda1 interferes with stabilization of the DNA by the host molecule HMGB1 protein, which may account for decreased IFN-1 levels at the site of infection.

Original languageEnglish
JournalThe Journal of investigative dermatology
Volume139
Issue number6
Pages (from-to)1284-1293
Number of pages10
ISSN0022-202X
DOIs
Publication statusPublished - Jun 2019

ID: 56108153