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Rigshospitalet - a part of Copenhagen University Hospital
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Glucocorticoid use and factors associated with variability in this use in the Systemic Lupus International Collaborating Clinics Inception Cohort

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  1. Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cardiovascular Manifestations of Systemic Sclerosis: A Danish Nationwide Cohort Study

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  3. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus

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  • Jayne Little
  • Ben Parker
  • Mark Lunt
  • John G Hanly
  • Murray B Urowitz
  • Ann E Clarke
  • Juanita Romero-Diaz
  • Caroline Gordon
  • Sang-Cheol Bae
  • Sasha Bernatsky
  • Daniel J Wallace
  • Joan T Merrill
  • Jill Buyon
  • David A Isenberg
  • Anisur Rahman
  • Ellen M Ginzler
  • Michelle Petri
  • Mary Anne Dooley
  • Paul Fortin
  • Dafna D Gladman
  • Kristjan Steinsson
  • Rosalind Ramsey-Goldman
  • Munther A Khamashta
  • Cynthia Aranow
  • Meggan Mackay
  • Graciela S Alarcón
  • Susan Manzi
  • Ola Nived
  • Andreas Jönsen
  • Asad A Zoma
  • Ronald F van Vollenhoven
  • Manuel Ramos-Casals
  • Guillermo Ruiz-Irastorza
  • Sung Sam Lim
  • Kenneth C Kalunian
  • Murat Inanc
  • Diane L Kamen
  • Christine A Peschken
  • Soren Jacobsen
  • Anca Askanase
  • Jorge Sanchez-Guerrero
  • Ian N Bruce
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Objectives: To describe glucocorticoid (GC) use in the SLICC inception cohort and to explore factors associated with GC use. In particular we aimed to assess temporal trends in GC use and to what extent physician-related factors may influence use.

Methods: Patients were recruited within 15 months of diagnosis of SLE from 33 centres between 1999 and 2011 and continue to be reviewed annually. Descriptive statistics were used to detail oral and parenteral GC use. Cross sectional and longitudinal analyses were performed to explore factors associated with GC use at enrolment and over time.

Results: We studied 1700 patients with a mean (s.d.) follow-up duration of 7.26 (3.82) years. Over the entire study period, 1365 (81.3%) patients received oral GCs and 447 (26.3%) received parenteral GCs at some point. GC use was strongly associated with treatment centre, age, race/ethnicity, sex, disease duration and disease activity. There was no change in the proportion of patients on GCs or the average doses of GC used over time according to year of diagnosis.

Conclusion: GCs remain a cornerstone in SLE management and there have been no significant changes in their use over the past 10-15 years. While patient and disease factors contribute to the variation in GC use, between-centre differences suggest that physician-related factors also contribute. Evidence-based treatment algorithms are needed to inform a more standardized approach to GC use in SLE.

Original languageEnglish
JournalRheumatology (Oxford, England)
Volume57
Issue number4
Pages (from-to)677-687
Number of pages11
ISSN1462-0324
DOIs
Publication statusPublished - 1 Apr 2018

    Research areas

  • Adult, Algorithms, Asia/epidemiology, Cross-Sectional Studies, Disease Progression, Dose-Response Relationship, Drug, Drug Prescriptions/statistics & numerical data, Ethnic Groups, Europe/epidemiology, Female, Follow-Up Studies, Glucocorticoids/administration & dosage, Health Status, Humans, International Cooperation, Lupus Erythematosus, Systemic/drug therapy, Male, Morbidity/trends, North America/epidemiology, Retrospective Studies, Risk Factors, Severity of Illness Index, Time Factors, Young Adult

ID: 56674652