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Rigshospitalet - a part of Copenhagen University Hospital

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

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  • Mariaelisa Graff
  • Robert A Scott
  • Anne E Justice
  • Kristin L Young
  • Mary F Feitosa
  • Llilda Barata
  • Thomas W Winkler
  • Audrey Y Chu
  • Anubha Mahajan
  • David Hadley
  • Luting Xue
  • Tsegaselassie Workalemahu
  • Nancy L Heard-Costa
  • Marcel den Hoed
  • Tarunveer S Ahluwalia
  • Qibin Qi
  • Julius S Ngwa
  • Frida Renström
  • Lydia Quaye
  • John D Eicher
  • James E Hayes
  • Marilyn Cornelis
  • Zoltán Kutalik
  • Elise Lim
  • Jian'an Luan
  • Jennifer E Huffman
  • Weihua Zhang
  • Wei Zhao
  • Paula J Griffin
  • Toomas Haller
  • Shafqat Ahmad
  • Pedro Marques-Vidal
  • Stephanie Bien
  • Loic Yengo
  • Alexander Teumer
  • Albert Vernon Smith
  • Meena Kumari
  • Marie Neergaard Harder
  • Johanne Marie Justesen
  • Marcus E Kleber
  • Mette Hollensted
  • Kurt Lohman
  • Natalia V Rivera
  • John B Whitfield
  • Jing Hua Zhao
  • Mette Aadahl
  • Kristine Færch
  • Henrik Vestergaard
  • Thorkild I A Sørensen
  • Allan Linneberg
  • CHARGE Consortium
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Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

Original languageEnglish
JournalP L o S Genetics
Issue number4
Pages (from-to)e1006528
Publication statusPublished - Apr 2017

    Research areas

  • Journal Article

ID: 50292870