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Rigshospitalet - a part of Copenhagen University Hospital
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Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis

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  • Nikolai Dyrberg Loft
  • Lone Skov
  • Mads Kirchheiner Rasmussen
  • Robert Gniadecki
  • Tomas Norman Dam
  • Ivan Brandslund
  • Hans Jürgen Hoffmann
  • Malene Rohr Andersen
  • Ram Benny Dessau
  • Ann Christina Bergmann
  • Niels Møller Andersen
  • Mikkel Kramme Abildtoft
  • Paal Skytt Andersen
  • Merete Lund Hetland
  • Bente Glintborg
  • Steffen Bank
  • Ulla Vogel
  • Vibeke Andersen
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BACKGROUND: Psoriasis (PsO) is a chronic inflammatory disease with predominantly cutaneous manifestations. Approximately one third of patients with PsO develop psoriatic arthritis (PsA), whereas the remaining proportion of patients has isolated cutaneous psoriasis (PsC). These two phenotypes share common immunology, but with different heredity that might in part be explained by genetic variables.

METHODS: Using a candidate gene approach, we studied 53 single nucleotide polymorphisms (SNPs) in 37 genes that regulate inflammation. In total, we assessed 480 patients with PsO from DERMBIO, of whom 151 had PsC for 10 years or more (PsC10), 459 patients with PsA from DANBIO, and 795 healthy controls. Using logistic regression analysis, crude and adjusted for age and gender, we assessed associations between genetic variants and PsO, PsC10, and PsA, as well as associations between genetic variants and development of PsA in PsO.

RESULTS: Eleven polymorphisms in 10 genes were nominally associated with PsO and/or PsC and/or PsA (P < 0.05). After correction for multiple testing with a false discovery rate of 5%, two SNPs remained significant: TNF (rs361525) was associated with PsO, PsC10, and PsA; and IL12B (rs6887695) was associated with PsO.

CONCLUSION: Among a cohort of Danish patients with moderate-to-severe psoriasis, two SNPs in the IL12B and TNF genes were associated with susceptibility of psoriasis. None of the SNPs were specifically associated with isolated cutaneous psoriasis or psoriatic arthritis.

Original languageEnglish
JournalPLoS One
Volume13
Issue number2
Pages (from-to)e0192010
ISSN1932-6203
DOIs
Publication statusPublished - 2018

Bibliographical note

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    Research areas

  • Arthritis, Psoriatic/complications, Denmark, Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide, Psoriasis/complications

ID: 55201382