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Genetic markers of abdominal obesity and weight loss after gastric bypass surgery

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  • Martin Aasbrenn
  • Mathilde Svendstrup
  • Theresia M Schnurr
  • Dorte Lindqvist Hansen
  • Dorte Worm
  • Marie Balslev-Harder
  • Niels Grarup
  • Kristoffer Sølvsten Burgdorf
  • Henrik Vestergaard
  • Oluf Pedersen
  • Lars Ängquist
  • Mogens Fenger
  • Thorkild I A Sørensen
  • Sten Madsbad
  • Torben Hansen
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BACKGROUND: Weight loss after bariatric surgery varies widely between individuals, partly due to genetic differences. In addition, genetic determinants of abdominal obesity have been shown to attenuate weight loss after dietary intervention with special attention paid to the rs1358980-T risk allele in the VEGFA locus. Here we aimed to test if updated genetic risk scores (GRSs) for adiposity measures and the rs1358980-T risk allele are linked with weight loss following gastric bypass surgery.

METHODS: Five hundred seventy six patients with morbid obesity underwent Roux-en-Y gastric bypass. A GRS for BMI and a GRS for waist-hip-ratio adjusted for BMI (proxy for abdominal obesity), respectively, were constructed. All patients were genotyped for the rs1358980-T risk allele. Associations between the genetic determinants and weight loss after bariatric surgery were evaluated.

RESULTS: The GRS for BMI was not associated with weight loss (β = -2.0 kg/100 risk alleles, 95% CI -7.5 to 3.3, p = 0.45). Even though the GRS for abdominal obesity was associated with an attenuated weight loss response adjusted for age, sex and center (β = -14.6 kg/100 risk alleles, 95% CI -25.4 to -3.8, p = 0.008), it was not significantly associated with weight loss after adjustment for baseline BMI (β = -7.9 kg/100 risk alleles, 95% CI -17.5 to 1.6, p = 0.11). Similarly, the rs1358980-T risk allele was not significantly associated with weight loss (β = -0.8 kg/risk allele, 95% CI -2.2 to 0.6, p = 0.25).

DISCUSSION: GRSs for adiposity derived from large meta-analyses and the rs1358980-T risk allele in the VEGFA locus did not predict weight loss after gastric bypass surgery. The association between a GRS for abdominal obesity and the response to bariatric surgery may be dependent on the association between the GRS and baseline BMI.

Original languageEnglish
Article numbere0252525
JournalPLoS One
Volume16
Issue number5
Pages (from-to)e0252525
ISSN1932-6203
DOIs
Publication statusPublished - 28 May 2021

Bibliographical note

Publisher Copyright:
© 2021 Aasbrenn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

ID: 65944144