Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Gastrin and the moderate hypergastrinemias

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. The collagen receptor uparap in malignant mesothelioma: A potential diagnostic marker and therapeutic target

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Classification of MSH6 Variants of Uncertain Significance Using Functional Assays

    Research output: Contribution to journalReviewResearchpeer-review

  3. Osteosarcoma and Metastasis Associated Bone Degradation-A Tale of Osteoclast and Malignant Cell Cooperativity

    Research output: Contribution to journalReviewResearchpeer-review

  4. HDL cholesterol and non-cardiovascular disease: a narrative review

    Research output: Contribution to journalReviewResearchpeer-review

  5. The Role of Leptin in Fetal Growth during Pre-Eclampsia

    Research output: Contribution to journalReviewResearchpeer-review

  1. Cholecystokinin and panic disorder: reflections on the history and some unsolved questions

    Research output: Contribution to journalReviewResearchpeer-review

  2. Liraglutide decreases postprandial fibroblast growth factor 19 and glucagon-like peptide 2, and increases postprandial cholecystokinin in individuals with obesity

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  3. Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy young men

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Expression of cholecystokinin and its receptors in the intestinal tract of type 2 diabetes patients and healthy controls

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The antral hormone gastrin potently regulates gastric acid secretion and fundic mucosal growth. Consequently, appropriate gastrin secretion and plasma concentrations are important for the early phases of digestion. This review describes as the first premise the normal biogenesis of gastrin in the antral mucosa, but also mentions the extraantral expression. Subsequently, the molecular nature and concentration levels of gastrin in serum or plasma are overviewed. Third, assays for accurate measurements of plasma or serum concentrations are commented. Finally, the problem of moderate hypergastrinemia due to Helicobacter pylori infections and/or treatment with proton-pump inhibitors (PPI) is discussed. The review concludes that accurate measurement of the true concentrations of bioactive gastrins in plasma is important. Moreover, it suggests that moderate hypergastrinemias are also essential health issues that require serious attention.

Original languageEnglish
Article number6977
JournalInternational Journal of Molecular Sciences
Volume22
Issue number13
ISSN1661-6596
DOIs
Publication statusPublished - 1 Jul 2021

    Research areas

  • Duodenal ulcer, Gastric cancer, Gastrin, Helicobacter pylori, Hypergastrinemia, Proton-pump inhibitors

ID: 66792356