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Gasotransmitters and the immune system: Mode of action and novel therapeutic targets

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Fagone, Paolo ; Mazzon, Emanuela ; Bramanti, Placido ; Bendtzen, Klaus ; Nicoletti, Ferdinando. / Gasotransmitters and the immune system : Mode of action and novel therapeutic targets. In: European Journal of Pharmacology. 2018 ; Vol. 834. pp. 92-102.

Bibtex

@article{dcd82b65ffc64967a36dfdd1b2816131,
title = "Gasotransmitters and the immune system: Mode of action and novel therapeutic targets",
abstract = "Gasotransmitters are a group of gaseous molecules, with pleiotropic biological functions. These molecules include nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO). Abnormal production and metabolism of these molecules have been observed in several pathological conditions. The understanding of the role of gasotransmitters in the immune system has grown significantly in the past years, and independent studies have shed light on the effect of exogenous and endogenous gasotransmitters on immune responses. Moreover, encouraging results come from the efficacy of NO-, CO- and H2S -donors in preclinical animal models of autoimmune, acute and chronic inflammatory diseases. To date, data on the influence of gasotransmitters in immunity and immunopathology are often scattered and partial, and the scarcity of clinical trials using NO-, CO- and H2S -donors, reveals that more effort is warranted. This review focuses on the role of gasotransmitters in the immune system and covers the evidences on the possible use of gasotransmitters for the treatment of inflammatory conditions.",
keywords = "Animals, Gasotransmitters/metabolism, Humans, Immune System/drug effects, Molecular Targeted Therapy/methods",
author = "Paolo Fagone and Emanuela Mazzon and Placido Bramanti and Klaus Bendtzen and Ferdinando Nicoletti",
note = "Copyright {\circledC} 2018 The Authors. Published by Elsevier B.V. All rights reserved.",
year = "2018",
month = "9",
day = "5",
doi = "10.1016/j.ejphar.2018.07.026",
language = "English",
volume = "834",
pages = "92--102",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Gasotransmitters and the immune system

T2 - Mode of action and novel therapeutic targets

AU - Fagone, Paolo

AU - Mazzon, Emanuela

AU - Bramanti, Placido

AU - Bendtzen, Klaus

AU - Nicoletti, Ferdinando

N1 - Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2018/9/5

Y1 - 2018/9/5

N2 - Gasotransmitters are a group of gaseous molecules, with pleiotropic biological functions. These molecules include nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO). Abnormal production and metabolism of these molecules have been observed in several pathological conditions. The understanding of the role of gasotransmitters in the immune system has grown significantly in the past years, and independent studies have shed light on the effect of exogenous and endogenous gasotransmitters on immune responses. Moreover, encouraging results come from the efficacy of NO-, CO- and H2S -donors in preclinical animal models of autoimmune, acute and chronic inflammatory diseases. To date, data on the influence of gasotransmitters in immunity and immunopathology are often scattered and partial, and the scarcity of clinical trials using NO-, CO- and H2S -donors, reveals that more effort is warranted. This review focuses on the role of gasotransmitters in the immune system and covers the evidences on the possible use of gasotransmitters for the treatment of inflammatory conditions.

AB - Gasotransmitters are a group of gaseous molecules, with pleiotropic biological functions. These molecules include nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO). Abnormal production and metabolism of these molecules have been observed in several pathological conditions. The understanding of the role of gasotransmitters in the immune system has grown significantly in the past years, and independent studies have shed light on the effect of exogenous and endogenous gasotransmitters on immune responses. Moreover, encouraging results come from the efficacy of NO-, CO- and H2S -donors in preclinical animal models of autoimmune, acute and chronic inflammatory diseases. To date, data on the influence of gasotransmitters in immunity and immunopathology are often scattered and partial, and the scarcity of clinical trials using NO-, CO- and H2S -donors, reveals that more effort is warranted. This review focuses on the role of gasotransmitters in the immune system and covers the evidences on the possible use of gasotransmitters for the treatment of inflammatory conditions.

KW - Animals

KW - Gasotransmitters/metabolism

KW - Humans

KW - Immune System/drug effects

KW - Molecular Targeted Therapy/methods

U2 - 10.1016/j.ejphar.2018.07.026

DO - 10.1016/j.ejphar.2018.07.026

M3 - Journal article

VL - 834

SP - 92

EP - 102

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

ER -

ID: 56669389