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Rigshospitalet - a part of Copenhagen University Hospital

Flavonoid intake and its association with atrial fibrillation

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  • Nicola P Bondonno
  • Kevin Murray
  • Catherine P Bondonno
  • Joshua R Lewis
  • Kevin D Croft
  • Cecilie Kyrø
  • Gunnar Gislason
  • Anne Tjønneland
  • Augustin Scalbert
  • Aedín Cassidy
  • Jonathan P Piccini
  • Kim Overvad
  • Jonathan M Hodgson
  • Frederik Dalgaard
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BACKGROUND & AIMS: Primary prevention of atrial fibrillation (AF) through behavioural and dietary modification is a critically important and unmet need. Flavonoids are bioactive dietary compounds with promising cardiovascular health benefits. Our aim was to investigate the association between flavonoid intake and clinically apparent AF.

METHODS: Baseline data from 55 613 participants of the Danish Diet, Cancer and Health Study, without AF, recruited between 1993 and 1997, were cross-linked with Danish nationwide registries. Total flavonoid and flavonoid subclass intakes were calculated from validated food frequency questionnaires using the Phenol-Explorer database. Associations between flavonoid intake and incident AF (first-time hospitalization or outpatient visit) were examined using restricted cubic splines based on Cox proportional hazards models.

RESULTS: During a median [IQR] follow-up of 21 [18-22] years, 7291 participants were diagnosed with AF. Total flavonoid intake was not statistically significantly associated with risk of incident AF in the whole cohort. However, compared to the lowest quintile, a total flavonoid intake of 1000 mg/day was associated with a lower risk of AF in smokers [0.86 (0.77, 0.96)] but not in non-smokers [0.96 (0.88, 1.06)], and a lower risk of AF in high alcohol consumers [>20 g/d: 0.84 (0.75, 0.95)] but not in low-to-moderate alcohol consumers [<20 g/d: 0.97 (0.89, 1.07)].

CONCLUSION: Intake of flavonoids was not significantly associated with a lower risk of incident AF. However, higher intakes of flavonoids may be beneficial for those at a higher risk of developing AF.

Original languageEnglish
JournalClinical Nutrition
Issue number12
Pages (from-to)3821-3828
Number of pages8
Publication statusPublished - Dec 2020

ID: 62107190