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Rigshospitalet - a part of Copenhagen University Hospital
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First wave of COVID-19 hospital admissions in Denmark: a Nationwide population-based cohort study

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  1. High rates of multi-drug resistant gram-negative organisms associated with surgical site infections in a teaching hospital in Ghana

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  2. Differences in mortality in patients undergoing surgery for infective endocarditis according to age and valvular surgery

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  3. Renal function in Ethiopian HIV-positive adults on antiretroviral treatment with and without tenofovir

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  1. The Impact of Immunosuppression on Chronic Kidney Disease in People Living With Human Immunodeficiency Virus: The D:A:D Study

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  2. Preserved postprandial suppression of bone turnover markers, despite increased fasting levels, in postmenopausal women

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  3. Venous thromboembolism and major bleeding in patients with COVID-19: A nationwide population-based cohort study

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  4. Echocardiographic abnormalities and predictors of mortality in hospitalized COVID-19 patients: the ECHOVID-19 study

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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease coronavirus disease 2019 (COVID-19), is a worldwide emergency. Demographic, comorbidity and laboratory determinants of death and of ICU admission were explored in all Danish hospitalised patients. Methods: National health registries were used to identify all hospitalized patients with a COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), and laboratory results on admission and explored prognostic factors for death using multivariate Cox proportional hazard regression and competing risk survival analysis. Results: Among 2431 hospitalised patients with COVID-19 between February 27 and July 8 (median age 69 years [IQR 53–80], 54.1% males), 359 (14.8%) needed admission to an intensive care unit (ICU) and 455 (18.7%) died within 30 days of follow-up. The seven-day cumulative incidence of ICU admission was lower for females (7.9%) than for males (16.7%), (p < 0.001). Age, high CCI, elevated C-reactive protein (CRP), ferritin, D-dimer, lactate dehydrogenase (LDH), urea, creatinine, lymphopenia, neutrophilia and thrombocytopenia within ±24-h of admission were independently associated with death within the first week in the multivariate analysis. Conditional upon surviving the first week, male sex, age, high CCI, elevated CRP, LDH, creatinine, urea and neutrophil count were independently associated with death within 30 days. Males presented with more pronounced laboratory abnormalities on admission. Conclusions: Advanced age, male sex, comorbidity, higher levels of systemic inflammation and cell-turnover were independent factors for mortality. Age was the strongest predictor for death, moderate to high level of comorbidity were associated with a nearly two-fold increase in mortality. Mortality was significantly higher in males after surviving the first week.

Original languageEnglish
Article number39
JournalBMC Infectious Diseases
Volume21
Issue number1
Pages (from-to)39
ISSN1471-2334
DOIs
Publication statusPublished - 9 Jan 2021

    Research areas

  • COVID-19, Epidemiology, Intensive care unit, Mortality, Nationwide, Prognostic factors, SARS-CoV-2

ID: 61728143